@font-face {
    font-family: 'Helvetica Neue';
    src: url('../fonts/HelveticaNeue-Regular.otf') format('truetype');
    font-weight: normal;
    font-style: normal;
}
@font-face {
    font-family: 'Helvetica Neue LT Pro';
    src: url('../fonts/HelveticaNeueLTPro-Bd.eot');
    src: url('../fonts/HelveticaNeueLTPro-Bd.eot?#iefix') format('embedded-opentype'),
        url('../fonts/HelveticaNeueLTPro-Bd.woff2') format('woff2'),
        url('../fonts/HelveticaNeueLTPro-Bd.woff') format('woff'),
        url('../fonts/HelveticaNeueLTPro-Bd.ttf') format('truetype'),
        url('../fonts/HelveticaNeueLTPro-Bd.svg#HelveticaNeueLTPro-Bd') format('svg');
    font-weight: bold;
    font-style: normal;
    font-display: swap;
}
@font-face {
    font-display: swap;
    font-family: Helvetica Neue LT Pro extend;
    font-style: normal;
    src: local("Helvetica-Neue"),url(../fonts/Linotype\ -\ HelveticaNeueLTPro-BlkEx.otf) format("opentype")
}
@font-face {
    font-display: swap;
    font-family: Helvetica Neue LT Pro light extend;
    font-style: normal;
    src: local("Helvetica-Neue"),url(../fonts/Helvetica\ Neue\ LT\ Pro\ 43\ Light\ Extended.otf) format("opentype")
}
html {
    height: 100%;
}
/* General */
body {
    font-family: "Inter", sans-serif;
    font-size: 16px;
    line-height: 24px;
    color: #171717;
    background-color: #ffffff;
    font-weight: 500;
    font-style: normal;
    box-sizing: border-box;
    margin: 0;
}

ul {
    padding: 0;
}

ul li {
    list-style: none;
}

img {
    width: 100%;
}

h1, h2 {
    font-family: "Inter", sans-serif;
}
h1 {
    font-size: 75px;
    line-height: 82px;
    font-weight: 900;
    margin-bottom: 30px;
    color: #FFFFFF;
}
h2 {
    color: #351A7C;
    font-size: 42px;
    font-weight: 400;
    line-height: 50px;
    margin-bottom: 20px;
}
h3 {
    font-size: 50px;
    line-height: 58px;
    font-weight: 400;
    color: #0D3169;
    margin-bottom: 30px;
}
h2 strong, h3 span, h3 strong, h4 strong {
    font-weight: bold;
}
h4 {
    font-family: "Inter", sans-serif;
    font-size: 24px;
    font-weight: 400;
    line-height: 32px;
    color: #1B0478;
    margin-bottom: 30px;
}
.navbar-expand-lg .navbar-nav .dropdown-menu {
    background: #ffffff;
    border: none;
    border-radius: 10px;
    padding: 10px 0;
    box-shadow: 0 0 20px rgba(0, 0, 0, 0.05);
}
.nav-item strong {
    color: #ffffff;
}
.grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 100px;
}
ul li {
    position: relative;
}
.small {
    font-size: 12px;
    line-height: 20px;
    color: #000000;
}
.pd-b {
    padding-bottom: 40px;
}
.badge-title, .badge-btn a {
    padding: 8px 12px;
    background-color: #E73695;
    border-radius: 10px;
    color: #ffffff;
    max-width: max-content;
    margin-bottom: 30px;
    display: inline-block;
}
.badge-btn a {
    padding: 15px 20px;
    align-self: end;
    font-size: 18px;
    line-height: 26px;
    color: #ffffff;
    text-decoration: none;
}
.container-btn {
    padding: 150px 0 30px;
    display: flex;
    align-items: flex-end;
    justify-content: end;
}
.badge-title p {
    font-weight: bold;
    margin-bottom: 0;
    text-transform: uppercase;
} 
.badge-title.purple {
    background-color: #351A7C;
    margin-bottom: 20px;
}
.impact-description {
    max-width: 650px;
    margin-bottom: 40px;
} 
.impact-list {
    list-style: none;
    padding-left: 0;
    margin: 0;
}
.impact-list li {
    position: relative;
    padding-left: 28px;
    margin-bottom: 15px;
    border-bottom: 1px dotted #FCD9E2;
    padding-bottom: 15px;
}
.impact-list li::before {
    content: "";
    position: absolute;
    left: 0;
    top: 2px;
    width: 16px;
    height: 16px;
    background-size: contain;
    background-repeat: no-repeat;
}
  /* Ícones específicos */
.impact-list li.info::before {
    background-image: url(../img/exclamacao.svg);
}
.impact-list li.arrow {
    padding-left: 40px; 
  }
.impact-list li.arrow::before {
    background-image: url(../img/arrow.svg); 
    width: 28px;
    height: 12px;
    left: 10px;
}
.grid.cards {
    grid-template-columns: repeat(3, 1fr);
    gap: 16px;
    padding: 20px 0 60px;
}
.grid.cards .card {
    background-color: #f4f1fa;
    color: #313131;
    padding: 60px 40px 20px 40px;
    border-radius: 30px;
    font-size: 18px;
    line-height: 26px;
    position: relative;
    border: none;
    box-shadow: 0 0 20px rgba(0, 0, 0, 0.025);
}
.grid.cards .card .icon {
    width: 20px;
    height: 20px;
    filter: brightness(0) saturate(100%) invert(10%) sepia(23%) saturate(7473%) hue-rotate(248deg) brightness(91%) contrast(96%);
    position: absolute;
    top: 30px;
    left: 40px;
}
.yellow-box {
    padding: 20px 30px 10px;
    font-size: 18px;
    line-height: 26px;
    background-color: #FFFAF0;
    color: #E19F16;
    margin: 60px 0 30px;
    position: relative;
}
.yellow-box::before, .pink-list li::before {
    content: '';
    background: url(../img/icon-relevance.svg);
    width: 20px;
    height: 20px;
    background-size: 20px;
    position: absolute;
    top: 22px;
    right: 65px;
}
.pink-list {
    list-style: none;
    padding: 0;
    margin: 0;
    font-family: Arial, sans-serif;
}
  
.pink-list li {
    background-color: #FFF4FA;
    color: #E73695;
    padding: 30px 10px 30px 20px;
    margin-bottom: 12px;
    position: relative;
}
.pink-list li p {
    margin: 0;
    font-size: 18px;
    line-height: 26px;
    font-weight: bold;
    max-width: 90%;
}
.pink-list li::before {
    background: url(../img/icon-pink-list.svg);
    top: 86px;
    right: 65px;
}

/* end General */

/* Section Banner */
.banner {
    padding: 100px 0 150px;
    position: relative;
    background: url(../img/banner.png) top center/cover no-repeat;
    height: 1105px;
    width: 100%;
    top: -170px;
}
.banner .title {
    padding: 180px 0 100px;
    color: #FFFFFF;
    max-width: 470px;
}
.banner .title p {
    max-width: 410px;
}
.banner nav {
    padding: 0;
    background-color: transparent; 
    position: relative;
    z-index: 99;
    margin-left: -20px;
}
.banner .navbar-expand-lg .navbar-nav {
    margin: 0;
}
.banner nav ul li, .about .grid .grid-item ul li {
    margin-bottom: 2px;
}
.banner nav ul li::before {
    display: none;
}
.navbar-expand-lg .navbar-nav {
    margin: 0 auto;
}
.banner nav .navbar-nav .nav-link {
    color: #ffffff;
    z-index: 9999;
    position: relative;
    padding: .5rem 25px;
    cursor: pointer;
}
.banner nav .navbar-nav .nav-item a.active {
   font-weight: bolder;
}
.banner .text-banner {
    padding-left: 5px;
    margin-top: 30px;
    color: #fff;
}
/* end Section Banner */

/* Section about */
.about {
    padding: 0 0 120px;
    position: relative;
    margin-top: -390px;
}
.about .grid {
    grid-template-columns: 45% 1fr;
    align-items: center;
    gap: 0;
}
.about .grid .grid-item img {
    position: relative;
    z-index: 99;
}
.info-button {
    padding: 15px 16px;
    background-color: #f7f7f7;
    border: none;
    border-radius: 4px;
    margin-top: 30px;
    display: inline-flex;
    align-items: center;
    gap: 8px;
}
.info-button a {
    font-size: 14px;
    font-weight: bold;
    text-decoration: none;
    color: #1A6EC0; 
    cursor: pointer;
}
.info-button .icon {
    height: 14px;
    width: 14px;
    vertical-align: middle;
}
.about .grid .grid-item-box {
    max-width: 900px;
    padding: 140px 90px 100px;
    background-color: #F9F9F9;
    border-radius: 50px 0 0 50px;
    position: absolute;
    right: 0;
    z-index: 9;
}
.about .grid .grid-item-box h2 {
    max-width: 440px;
    margin-bottom: 20px;
}
.about .grid .grid-item-box p {
    max-width: 469px;
    margin-bottom: 60px;
}
.about .grid .grid-item ul.badges {
    list-style: none;
    padding: 0;
    display: flex;
    flex-wrap: wrap;
    gap: 12px;
}
.badge {
    display: inline-flex;
    align-items: center;
    gap: 8px;
    color: white;
    font-weight: bold;
    border-radius: 40px;
    padding: 10px 25px 10px 10px;
    font-size: 14px;
    position: relative;
    margin-bottom: 8px;
}
  
.badge::before {
    content: "";
    background: url(../img/check.svg);
    background-size: 47px;
    color: #5c5c5c;
    font-weight: bold;
    border-radius: 50%;
    display: inline-flex;
    align-items: center;
    justify-content: center;
    width: 47px;
    height: 47px;
    font-size: 12px;
}
.badge.blue {
    background-color: #2276d3;
}
.badge.purple {
    background-color: #c48dd7;
} 
.badge.pink {
    background-color: #ed4b9e;
} 
.badge.dark-purple {
    background-color: #3f2a7e;
}
/* end Section about */

/* Section history */
.history {
    padding-bottom: 100px;
}
.history h2 {
    color: #1A6EC0;
    margin-bottom: 60px;
}
/* end Section history */

/* Section epdemiology */
.epdemiology {
    padding: 100px 0 0;
    background-color: #F9F9F9;
}
.epdemiology .prevalence-box {
    background-color: #ffffff;
    border-radius: 30px;
    padding: 30px 50px 50px 30px;
    display: inline-block;
    font-family: sans-serif;
    box-shadow: 0 0 20px rgba(0, 0, 0, 0.025);
    margin-top: 50px;
}
.epdemiology .label {
    background-color: #3f2a7e;
    color: #ffffff;
    font-size: 18px;
    line-height: 24px;
    font-weight: bold;
    padding: 8px 20px;
    border-radius: 10px;
    display: inline-block;
    margin-bottom: 30px;
    text-transform: uppercase;
}
.epdemiology .values {
    display: flex;
    align-items: center;
    gap: 4px;
    flex-wrap: wrap;
}
.epdemiology .values span {
    font-size: 104px;
    line-height: 54px;
    font-weight: bold;
}
.epdemiology .value-purple {
    color: #351A7C;
}
.epdemiology .slash {
    font-weight: normal;
    color: #000;
}
.epdemiology span.value-black {
    color: #000;
    font-weight: normal;
}
.epdemiology .values span.people {
    font-size: 18px;
    line-height: 24px;
    text-transform: uppercase;
    color: #000;
    margin-left: 4px;
}
.epdemiology .grid {
    grid-template-columns: 1fr 60%;
    gap: 20px;
}
.epdemiology .grid .prevalence-box {
    padding: 40px 40px 0;
    margin-top: 30px;
}
.epdemiology .prevalence-box:nth-child(4) {
    padding-right: 200px;
    padding-bottom: 20px;
    font-size: 18px;
    margin-top: 30px;
}
.epdemiology .prevalence-box:nth-child(4) .values {
    margin-bottom: 30px;
}
.epdemiology .impact-section {
    padding: 50px 0;
}

/* end Section epdemiology */

/* Section scenario */
.scenario {
    padding-bottom: 50px;
    background-color: #F9F9F9;
}
.scenario .grid.cards .card.destaque {
    background-color: #351A7C;
    color: #fff;
}
.scenario .grid.cards .card.destaque .icon {
    filter: brightness(0) invert(1);
}
.scenario h4 {
    max-width:  890px;
}

.scenario .scenario-box {
    padding: 50px 40px 20px;
    background-color: #ffffff;
    border-radius: 30px;
    margin-bottom: 30px;
}
.scenario .scenario-box .img {
    text-align: center;
    margin: 0 auto;
}
.scenario .scenario-box .img img {
    max-width: 885px;
}.scenario .scenario-box ul.badges {
    margin: 30px 0 40px;
}
.scenario .scenario-box ul.badges li.badge.dark-purple {
    background-color: #5936E7;
}
.scenario .scenario-box ul.badges li.badge.orange {
    background-color: #E75936;
}
.scenario .scenario-box ul.badges li.badge::before {
    background: url(../img/exclamacao.svg);
    background-color: #ffffff;
    background-position: center;
    background-size: 20px;
    background-repeat: no-repeat;
}
.scenario .scenario-box .small.grey {
    color: #686868;
}
/* end Section scenario */

/* Section ref-footer */
.ref-footer {
    padding: 100px 0;
}
.ref-footer p {
    font-size: 12px;
    line-height: 20px;
    color: #374151;
}
.ref-footer p strong {
    font-size: 14px;
}
.ref-footer p:last-child {
    margin-bottom: 0;
}
.accordion-item{
    border-radius: 0 0 10px 10px;
}
.accordion-item:last-of-type {
    border: none;
}
.accordion-item:first-of-type .accordion-button {
    background-color: #1A6EC0;
    color: #fff;
    border-radius: 10px;
    padding: 20px 30px;
    font-size: 18px;
}
.accordion-button:not(.collapsed)::after, .accordion-button::after {
    filter: brightness(0) invert(1);
}
.accordion-item:last-of-type .accordion-collapse {
    background: transparent;
}
.accordion-body {
    padding: 60px 40px 40px;
    background-color: #F9F9F9;
    border-radius: 0 0 10px 10px;
    margin-top: -10px;
}
/* end Section ref-footer */

/* Section Footer */
.footer {
    padding: 30px 0;
    position: relative;
    background: url(../img/img-footer.png) bottom center / cover no-repeat;
    height: 265px;
    width: 100%;
}
.footer .container-fluid {
    padding: 0 150px;
}
.footer .grid {
    grid-template-columns: 1fr 2fr 1fr;
    align-items: center;
    gap: 230px;
}
.footer .grid .grid-item {
    display: flex;
    align-items: center;
    justify-content: center;
}
.footer h4 {
    color: #690239;
    max-width: 525px;
    margin: 0 0 0 -50px;
    position: relative;
}
.footer h4::before {
    content: '';
    width: 6px;
    height: 108px;
    background-color: #690239;
    position: absolute;
    left: -30px;
    top: 0;
    z-index: 999;
}
.footer .btn-footer a {
    padding: 12px 65px;
    font-weight: bold;
    background-color: #59013D;
    color: #ffffff;
    border-radius: 100px;
    text-decoration: none;
    margin: auto;
    display: inline-block;

}
/* end Section Footer */

/* Section ref-br */
.ref-br {
    padding: 30px 0 10px;
   
}
.ref-br .small {
    color: #374151;
}
/* end Section ref-br */

/* Fisiopatologia Sobre */
.fisio .banner .title {
    padding: 270px 0 120px;
}
.fisio .banner .title h1 {
    font-size: 55px;
    line-height: 82px;
    margin-bottom: 20px;
}
.fisio .about-fisio, .fisio.two .deregulation, .fisio.three .cytokines, .fisio.four .relevance {
    padding: 70px 0;
    background-color: #ffffff;
    border-radius: 80px 80px 0 0;
    margin-top: -520px;
    position: relative;
    z-index: 9;
}
.fisio .about-fisio p {
    max-width: 895px;
    margin-bottom: 50px;
}
.fisio .about-fisio p.small {
    color: #686868;
}
.fisio .about-fisio .container-btn {
    padding: 0;
}
.fisio .ref-footer {
    padding-top: 0;
    padding-bottom: 70px;
}
/* end Fisiopatologia Sobre */

/* Fisiopatologia Desregulação */
.fisio.two .deregulation h4, .fisio.three .cytokines h4, .fisio.four .relevance h4, .impact .about.impact-het  h4 {
    max-width: 970px;
    color: #1A6EC0;
}
.fisio.two .deregulation .deregulation-box {
    padding: 50px 40px 40px;
    background-color: #F2F1F3;
    color: #171717;
    border-radius: 20px;
    margin-top: 100px;
}
.fisio.two .deregulation .deregulation-box p.small, .fisio.three .cytokines p.small, .fisio.four .relevance p.small {
    color: #686868;
}
.fisio.two .deregulation .container-btn, .fisio.three .cytokines .container-btn, .fisio.four .relevance .container-btn {
    padding: 80px 0 10px;
}
/* end Fisiopatologia Desregulação */

/* Fisiopatologia Papel das Citocinas */
.fisio.three .cytokines .impact-list {
    padding: 120px 0 20px;
}
.fisio.three .cytokines .badge-title.purple {
    margin-top: 40px;
}
.fisio.three .cytokines .img img {
    max-width: 1095px;
}
/* end Fisiopatologia Papel das Citocinas */

/*  Fisiopatologia Relevancia do IFN-1 */
.fisio.four .relevance .img:nth-child(3) {
    padding: 30px 50px 0 70px;
}
.fisio.four .relevance h4 {
    margin:  0 auto 90px;
}
.fisio.four .relevance p.small {
    max-width: 499px;
    margin-top: 80px;
}
/* end Fisiopatologia Relevancia do IFN-1 */

/* Pagina Diagnostico */
.diagnosis .banner .title {
    padding: 280px 0 100px;
}
.diagnosis .about.diagnosis-page, .impact .about.impact-het {
    margin-top: -370px;
}
.diagnosis .about.diagnosis-page.about .grid .grid-item-box {
    min-width: 1070px;
    padding-right: 80px;
}
.diagnosis .about.diagnosis-page.about .grid .grid-item-box h2 {
    max-width: 400px;
    margin-bottom: 30px;
}
.diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(2) {
    margin-bottom: 50px;
    position: relative;
}
.diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(2)::before {
    content: '';
    width: 786px;
    height: 140px;
    background: url(../img/detail.svg);
    background-size: 786px;
    position: absolute;
    top: 30px;
    right: 132px;
}
.diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(3) {
    padding-left: 30px;
}
.diagnosis .about.diagnosis-page.about .grid .grid-item-box .badge {
    gap: 10px;
    padding: 10px 35px 10px 15px;
    font-size: 16px;
}
.diagnosis .about.diagnosis-page.about .grid .grid-item-box p.small {
    color: #5c5c5c;
}
.diagnosis .challenges {
    padding: 100px 0 20px;
}
.diagnosis .challenges .grid.cards {
    padding-bottom: 0;
}
.diagnosis .challenges .grid.cards .card {
    padding: 60px 150px 20px 40px;
} 
.diagnosis .challenges .grid.cards .card:last-child {
    padding: 60px 45px 20px 40px;
} 
.diagnosis .challenges .yellow-box {
    padding: 30px 140px 20px 40px;
    margin: 20px 0;
}
.diagnosis .challenges .yellow-box:nth-child(3)::before {
    top: 84px;
    left: 15%;
}
.diagnosis .challenges .yellow-box:nth-child(4)::before {
    top: 85px;
    left: 166px;
}
.diagnosis .challenges h4:last-child {
    max-width: 1010px;
    margin-top: 40px;
}
.colors-section .grid {
    grid-template-columns: 2.5fr 1fr;
    gap: 10px;
    margin: 40px 0 20px;
}
.colors-section .grid .colors-box {
    position: relative;
    flex: 1 1 300px;
    border-radius: 0 10px 10px 0;
    padding: 30px 16px 30px;
    background: #F3D1E3;
}
.colors-section .grid .colors-box.muscle {
    padding: 30px 20px;
    background: #E9D1F3;
    border-radius: 10px 0 0 10px;
}
.colors-section .grid .colors-box .colors-title {
    position: absolute;
    top: -17px;
    left: 22%;
    background: #E73695;
    color: white;
    padding: 8px 12px;
    font-size: 20px;
    line-height: 22px;
    font-weight: bold;
    border-radius: 10px;
    text-transform: uppercase;
}
.colors-section .grid .colors-box.muscle .colors-title {
    left: 12px;
    background: #BC7DD4;
}
.colors-section .grid .colors-box .colors-list {
    padding: 10px 90px 20px 0;
    margin-top: 20px;
    display: flex;
    justify-content: flex-end;
    flex-wrap: wrap;
    gap: 60px;
    align-items: center;
}
.colors-section .grid .colors-box.muscle .colors-list {
    justify-content: flex-start;
}
.colors-section .grid .colors-box .colors-list span {
    white-space: nowrap;
}

.colors-section.blue .grid {
    grid-template-columns: 1fr 1fr;
}
.colors-section.blue .grid .colors-box {
    background-color: #D9D9F0;
}
.colors-section.blue .grid .colors-box.muscle {
    background-color: #D1DCF3;
}
.colors-section.blue .grid .colors-box .colors-title {
    background-color: #351A7C;
    left: 31%;
}
.colors-section.blue .grid .colors-box.muscle .colors-title {
    background-color: #1A6EC0;
    left: 12px;
}
.pink .pink-box {
    padding: 20px 0 10px;
    text-align: center;
    background-color: #E73695;
    color: #ffffff;
    border-radius: 6px;
}
.diagnosis .ref-footer {
    padding: 50px;
}
.diagnosis .ref-footer .container-btn {
    padding: 0 0 50px;
}
/* end Pagina Diagnostico */

/* Pagina Impacto Heterogeneidade do LES */
.impact .about.impact-het h2 {
    max-width: 525px;
}
.impact .about.impact-het .grid .grid-item {
    padding: 40px 20px 20px 20px;
    background-color: #ffffff;
    border-radius: 123px 15px 124px 15px;
    position: relative;
    z-index: 99;
    box-shadow: 0 0 20px rgba(0, 0, 0, 0.05);
}
.impact .about.impact-het .grid .grid-item-box {
    padding: 70px 90px 90px;
}
.impact .about.impact-het .grid .grid-item-box p {
    max-width: 100%;
    margin-bottom: 30px;
}
.impact .about.impact-het .grid .grid-item-box p:nth-child(2) {
    max-width: 507px;
}
.impact .about.impact-het .grid .grid-item-box ul {
    margin-bottom: 30px;
}
.impact .about.impact-het .grid .grid-item-box ul li p {
    font-size: 16px;
    margin-bottom: 0;
}
.impact .about.impact-het .grid .grid-item-box .badge.pink, .impact .damage .badge.pink {
    background-color: #B82574;
}
.impact .about.impact-het h4 {
    max-width: 640px;
}
.impact .about.impact-het .grid .grid-item-box p:nth-child(5) {
    max-width: 420px;
}
/* end Pagina Impacto Heterogeneidade do LES */

/* end Pagina Impacto Uso De Corticoides */
.impact .banner .title.different {
    padding: 190px 0 120px;
}
.impact .about.impact-cort .grid {
    display: block;
}
.impact .about.impact-cort .grid .grid-item-box {
    max-width: 97%;
    padding: 70px 100px 20px;
    border-radius: 0 50px  50px 0;
    top: -40%;
    left: 0;
    box-shadow: 0 0 20px rgba(0, 0, 0, 0.10)
}
.impact .about.impact-cort .grid .grid-item-box h2 {
    max-width: 100%;
}
.impact .illness {
    padding: 170px 0 80px;
}
.impact .illness h4 {
    max-width: 553px;
}
.impact .illness .grid {
    gap:20px;
    margin-bottom: 50px;
}
.impact .illness .grid .illness-box {
    padding: 20px 30px 30px 20px;
    background-color: #b7b5bc14;
    border-radius: 30px;
    box-shadow: 0 0 20px rgba(0, 0, 0, 0.10)
}
.impact .illness p.small {
    color: #171717;
}
.impact .yellow-box {
    padding: 30px 30px 20px;
}
.impact .yellow-box::before {
    top: 32px;
    right: 210px;
}
.impact .study {
    padding: 120px 0;
    background-color: #FAFAFA;
}
.impact .study h4, .impact .damage h4 {
    max-width: 1221px;
    color: #1A6EC0;
}
.impact .study .badge-title.purple {
    margin: 90px 0 30px;
}
.impact .study .yellow-box {
    background-color: #FFF0D1;
    margin: 40px 0 80px;
}
.impact .study .yellow-box::before {
    right: 32%;
}
.impact .risks {
    padding: 120px 0;
}
.grey-box {
    padding: 70px 20px 30px 20px;
    background-color: rgb(183, 181, 188, 0.08);
    border-radius: 30px;
    margin-top: 20px;
}
.impact .risks .grey-box:nth-child(3) .img {
    text-align: center;
    margin: 0 auto;
}
.impact .risks .grey-box:nth-child(3) .img img {
    max-width: 814px;
}
.impact .risks .grey-box:nth-child(3) p {
    max-width: 1007px;
    margin: 40px auto 30px;
}
.impact .risks .grey-box:nth-child(4) .img img {
    max-width: 1120.5px;
    margin-left: 50px;
}
.impact .risks .yellow-box::before {
    right: 36%;
}

.impact .damage p:nth-child(2) {
    max-width: 986px;
}
.impact .damage .badge-title.purple:nth-child(6), .impact .damage .badge-title.purple:nth-child(10), .impact .damage .grid.third .badge-title.purple:nth-child(1) {
    margin-bottom: 3px;
}
.impact .damage .badge-title.purple:nth-child(7), .impact .damage .badge-title.purple:nth-child(11) {
    margin-bottom: 10px;
} 
.impact .damage .grey-box {
    padding: 0 30px 40px 40px;
    margin-top: 10px;
}
.impact .damage .grid {
    grid-template-columns: 1.45fr 1fr;
    gap: 20px;
    margin-bottom: 10px;
}
.impact .damage .grid .pink-list {
    margin-top: 60px;
}
.impact .damage .grid .pink-list li:last-child::before {
    top: 112px;
    right: 90px;
}
.impact .damage p.small {
    margin-bottom: 70px;
}
.impact .damage .grid.second .grey-box {
    padding: 70px 20px 60px 90px;
    margin: auto;
}
.impact .damage .grid.second .pink-list {
    margin-top: 0;
}
.impact .damage .grid.second .pink-list li::before {
    right: 46%;
}
.impact .damage .grid.second .pink-list li:nth-child(2):before {
    top: 112px;
    right: 78%;
}
.impact .damage .grid.second .pink-list li:nth-child(3):before {
    top: 86px;
    right: 45%;
}
.impact .damage .balance img {
    max-width: 1003px;
    margin: 20px 0 0 100px;
}
.impact .damage .balance p.small:nth-child(2) {
    margin-top: 80px;
}
.impact .damage .balance p.small {
    max-width: 1176px;
    color: #8C8C8C;
    margin-bottom: 20px;
}
.impact .damage .grey-box.mg-t {
    padding: 30px 70px 40px 30px;
    margin: 80px 0 90px;
}
.impact .damage .grid.third .grey-box {
    padding: 50px 60px 60px 70px;
}
.impact .damage .grid.third .pink-list {
    margin: 110px 0 40px;
}
.impact .damage .grid.third p.small {
    max-width: 380px;
}
.impact .damage .grid.third .pink-list li::before {
    top: 62px;
    right: 43%;
}
.impact .damage .grid.third .pink-list li:last-child:before {
    top: 82px;
    right: 65%;
}
.impact.corticosteroids .ref-footer {
    padding-top: 30px;
}
/* end Pagina Impacto Uso De Corticoides */

/* Responsive */
@media (max-width: 1850px) {
    .diagnosis .about.diagnosis-page .grid {
        grid-template-columns: 39% 1fr;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(2)::before {
        right: 117px;
    }
}
@media (max-width: 1820px) {
    .footer .btn-footer a {
        padding: 12px 48px;
    }
}
@media (max-width: 1700px) {
    .about .grid .grid-item-box {
        max-width: 880px;
    }
    .footer {
        height: 220px;
    }
    .footer .container-fluid {
        padding: 0 80px;
    }

    .diagnosis .about.diagnosis-page .grid {
        grid-template-columns: 32% 1fr;
    }
    .diagnosis .about.diagnosis-page .grid .grid-item-box {
        padding: 90px 50px 50px 90px;
    }
}
@media (max-width: 1540px) {
    .banner {
        height: 1050px;
    }
    .about {
        margin-top: -340px;
    }
    .about .grid .grid-item-box {
        max-width: 850px;
    }
    .about .grid {
        grid-template-columns: 44% 1fr;
    }
    .footer .container-fluid {
        padding: 0 20px;
    }
    .footer .grid {
        gap: 150px;
    }

    .diagnosis .about.diagnosis-page {
        margin-top: -350px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box {
        min-width: 1030px;
        padding: 50px 20px 10px 112px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(2)::before {
        right: 118px;
        height: 136px;
    }
    .colors-section .grid .colors-box .colors-list {
        padding-right: 50px;
        gap: 50px;
    }
    .fisio.two .deregulation, .fisio.three .cytokines, .fisio .about-fisio {
        margin-top: -430px;
    }
     .impact .about.impact-het {
    margin-top: -280px;
}
 
}
@media (max-width: 1400px) {
    .banner {
        height: 955px;
    }
    .banner .title {
        padding: 150px 0 40px;
    }
    .banner nav .navbar-nav .nav-link {
        padding: .5rem 12px;
    }
    .about {
        margin-top: -345px;
    }
    .about .grid {
        grid-template-columns: 38% 1fr;
    }
    .about .grid .grid-item-box {
        padding: 80px 90px 50px;
    }
    .footer {
        height: 180px;
    }

    /* Pagina Diagnostico */
    .diagnosis .about.diagnosis-page {
        margin-top: -220px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box {
        min-width: 942px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box h2 {
        max-width: 518px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(2)::before {
        right: 32px;
    }
    .diagnosis .challenges .grid.cards .card {
        padding: 60px 40px 20px 40px;
    }
    .diagnosis .challenges .grid.cards .card:last-child {
        padding: 60px 10px 20px 30px;
    }
    .diagnosis .challenges .yellow-box:nth-child(3)::before {
        top: 84px;
        left: 43%;
    }
    .diagnosis .challenges .yellow-box:nth-child(4)::before {
        top: 85px;
        left: 41%;
    }
    .colors-section .grid .colors-box .colors-list {
        padding-right: 0px;
        gap: 30px;
    }
    .colors-section.blue .grid .colors-box .colors-list {
        padding-right: 70px;
    }
    /*end  Pagina Diagnostico */

    /* Pagina Impacto Uso De Corticoides */
    .impact.corticosteroids .about.impact-cort {
        margin-top: -320px;
    }
    .impact.corticosteroids .illness {
        padding: 230px 0 80px;
    }
    .impact.corticosteroids .yellow-box::before {
        right: 30px;
    }
    .impact.corticosteroids .study .yellow-box::before {
        right: 20%;
    }
    .impact.corticosteroids .risks .grey-box:nth-child(4) .img img {
        width: 90%;
    }
    .impact.corticosteroids .risks .yellow-box::before {
        right: 26%;
    }
    .impact.corticosteroids .damage .grid .pink-list {
        margin-top: 52px;
    }
    .impact.corticosteroids .damage .grid .pink-list li::before {
        top: 110px;
        right: 100px;
    }
    .impact.corticosteroids .damage .grid .pink-list li:last-child::before {
        top: 136px;
        right: 104px;
    }
    .impact.corticosteroids .damage .grid.second {
        row-gap: 0;
        align-items: flex-start;
    }
    .impact.corticosteroids .damage .grid.second .grey-box {
        height: 94%;
    }
    .impact.corticosteroids .damage .grid.second .pink-list {
        margin-top: 10px;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li p {
        font-size: 16px;
        line-height: 24px; 
    }
    .impact.corticosteroids .damage .grid.second .pink-list li::before {
        top: 80px;
        right: 131px;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li:nth-child(2):before {
        top: 104px;
        right: 70%;
    }
    .impact.corticosteroids .damage .grid.third {
        align-items: center;
    }
    .impact.corticosteroids .damage .grid.third .pink-list {
        margin-top: 155px;
    }
    .impact.corticosteroids .damage .grid.third .pink-list li::before {
        top: 56px;
        right: 45px;
    }
    .impact.corticosteroids .damage .grid.third .grid-item .pink-list li:nth-child(2)::before {
        top: 82px;
        right: 37%;
    }
    /* end Pagina Impacto Uso De Corticoides */
        .fisio.two .deregulation, .fisio.three .cytokines, .fisio .about-fisio {
        margin-top: -380px;
    } 
    .impact .about.impact-het {
        margin-top: -220px;
        margin-bottom: 80px;
    }
    .impact .about.impact-het h2 {
    max-width: 100%;
}
}
@media (max-width: 1280px) { 
    .banner {
        top: -195px;
    }
    .banner .title {
        padding: 190px 0 40px;
    }
    .banner nav {
        margin-left: 0;
    }
    .banner nav .navbar-nav .nav-link {
        padding: .5rem 8px;
    }
    .about {
        margin-top: -260px;
        padding-bottom: 200px;
    }
    .about .grid .grid-item-box {
        max-width: 670px;
        padding: 40px 20px 20px 90px;
    }
    .scenario .grid.cards .card {
        padding: 60px 20px 20px 30px;
    }
    .scenario .grid.cards .card p br {
        display: none;
    }
    .footer .grid {
        gap: 90px;
    }
    .footer .container-fluid {
        padding: 0 10px;
    }
    .footer .btn-footer a {
        padding: 12px 30px;
    }

    /* Pagina Diagnostico */
    .diagnosis .about.diagnosis-page .grid .grid-item img {
        display: none;
    }
    .diagnosis .about.diagnosis-page {
        margin-top: -110px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box p.small {
        margin-bottom: 30px;
    }
    .diagnosis .challenges {
        padding: 150px 0 20px;
    }
    .diagnosis .challenges .grid.cards .card {
        padding: 60px 35px 20px 40px;
    }
    .diagnosis .challenges .yellow-box:nth-child(3)::before {
        left: 43%;
    }
    .diagnosis .challenges .yellow-box:nth-child(4)::before {
        left: 84%;
    }
    .colors-section .grid .colors-box .colors-list {
        padding-right: 0;
        gap: 22px;
    }
    .colors-section.blue .grid .colors-box .colors-list {
        padding-right: 0px;
    }
    /*end  Pagina Diagnostico */

    /* Pagina Impacto Uso De Corticoides */
    .impact.corticosteroids .illness {
        padding: 130px 0 80px;
    }
    .impact.corticosteroids .illness .yellow-box::before {
        top: 58px;
        right: 77%;
    }
    .impact.corticosteroids .study .yellow-box::before {
        top: 32px;
        right: 7%;
    }
    .impact.corticosteroids .risks .yellow-box::before {
        right: 11%;
    }
    .impact.corticosteroids .damage .yellow-box::before {
        top: 59px;
        right: 70%;
    }
    .pink-list li p {
        font-size: 16px;
        line-height: 24px;
    }
    .impact.corticosteroids .damage .grid .pink-list li::before {
        top: 100px;
        right: 61px;
    }
    .impact.corticosteroids .damage .grid .pink-list li:last-child::before {
        top: 124px;
        right: 65px;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li p {
        font-size: 14px;
        line-height: 22px;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li::before {
        top: 73px;
        right: 59px;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li:nth-child(2):before {
        top: 94px;
        right: 40%;
    }
    .impact.corticosteroids .damage .grid .pink-list li:last-child::before {
        right: 68px;
    }
    .impact .damage .balance img {
        width: 80%;
    }
    .impact.corticosteroids .damage .grid.third .pink-list li::before {
        top: 78px;
        right: 57%;
    }
    .impact.corticosteroids .damage .grid.third .grid-item .pink-list li:nth-child(2)::before {
        top: 78px;
        right: 33%;
    }
    /* end Pagina Impacto Uso De Corticoides */
    .about .grid .grid-item-box {
        position: unset;
    }
    .about .grid {
        grid-template-columns: 1fr;
    }
    .impact .about.impact-het .grid .grid-item-box, .impact .about.impact-het .grid .grid-item {
        padding: 50px;
        border-radius: 30px;
        margin-bottom: 20px;
        max-width: 100%;
    }
    .impact .about.impact-het {
        padding-bottom: 0;
    }
    .impact .about.impact-het {
        margin-top: -463px;
        margin-bottom: 80px;
    }
}
@media (max-width: 1199px) {
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box {
        min-width: 100%;
    }

    .diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(2)::before {
        display: none;
    }

    .diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(3) {
        padding-left: 0;
        margin-top: -40px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box {
        min-width: 1030px;
        padding: 50px 20px 10px 70px;
    }
    .diagnosis .challenges .yellow-box {
        padding: 30px 120px 20px 40px;
    }
    .diagnosis .challenges .yellow-box:nth-child(3)::before {
        left: 87%;
    }
    section.scrool-l {
        width: 100%;
        overflow: auto;
    }
        .scrool-l .colors-section {
        max-width: none !important;
        width: 1250px;
    }
}
@media (max-width: 991px) {
    .banner {
        background-position-x: -565px;
        height: 880px;
    }
    .banner nav {
        padding: 0;
        width: max-content;
        background-color: #ffffff;
        border-radius: 10px;
    }
    .banner nav ul li {
        padding: 10px 20px;
        min-width: 330px;
    }
    .banner nav .navbar-nav .nav-link {
        padding: .5rem 15px;
        color: #351A7C;
    }
    .navbar-toggler {
        border-color: #351A7C;
        padding: 18px;
        border-radius: 0;
        border-radius: 10px;
    }
    .navbar-toggler .content {
        display: flex;
        flex-direction: column;
        justify-content: space-between;
        height: 24px;
        width: 30px;
    }
    .navbar-toggler .content span {
        display: block;
        height: 3px;
        width: 100%;
        background-color: #351A7C;
        transition: all 0.3s ease;
    }
    .img img {
        max-width: none!important;
        width: unset;
    }
    .img {
        width: 100%;
        overflow: auto;
    }
    .grid  {
        grid-template-columns: 1fr;
        gap: 30px;
    }
    .about .grid {
        display: flex;
        flex-direction: column-reverse;
        align-items: end;
        gap: 20px;
    }
    .about {
        position: sticky;
        margin-top: -240;
        padding-bottom: 50px;
    }
    .about .grid .grid-item img {
        display: none;
    }
    .about .grid .grid-item-box {
        max-width: 730px;
        padding: 40px 20px 20px 50px;
    }
    .info-button {
        position: sticky;
        top: 40px;
        right: 20px;
    }
    .badge {
        padding: 10px 20px 10px 10px;
    }
    .epdemiology .values span {
        font-size: 84px;
    }
    .epdemiology .prevalence-box:nth-child(4) {
        padding-right: 120px;
    }
    .scenario .grid.cards .card {
        font-size: 16px;
        line-height: 24px;
    }
    .scenario .grid.cards .card {
        padding: 60px 20px 10px 20px;
    }
    .scenario .grid.cards .card .icon {
        left: 20px;
    }
    .scenario .container-btn {
        padding: 100px 0 30px;
    }
    .footer .grid {
        gap: 40px;
    }
    .footer h4 {
        margin: 0 0 0 -10px;
    }
    .footer .btn-footer a {
        padding: 12px 15px;
    }

    /* Pagina Diagnostico */
    .diagnosis .banner .title {
        padding: 200px 0 50px;
    }
    .diagnosis .about.diagnosis-page {
        margin-top: -95px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box {
        min-width: 95%;
        top: -325px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box .badges:nth-child(2)::before {
        top: 128px;
        right: 193px;
        width: 500px;
        height: 89px;
        background-size: 500px;
    }
    .diagnosis .challenges .grid.cards {
        grid-template-columns:  1fr;
    }
    /*end  Pagina Diagnostico */

    /* Pagina Impacto Uso De Corticoides */
    .impact.corticosteroids .banner .title.different {
        padding: 190px 0 20px;
    }
    .impact.corticosteroids .illness .yellow-box::before {
        top: 58px;
        right: 28%;
    }
    .impact.corticosteroids .study .yellow-box::before {
        top: 58px;
        right: 62%;
    }
    .impact.corticosteroids .risks .yellow-box::before {
        top: 58px;
        right: 65%;
    }
    .impact.corticosteroids .damage .yellow-box::before {
        top: 59px;
        right: 28%;
    }
    .impact .damage .grid {
        grid-template-columns: 1fr;
    }
    .impact.corticosteroids .damage .grid .pink-list {
        margin-top: 0;
    }
    .impact.corticosteroids .damage .grid .pink-list li::before {
        top: 56px;
        right: 81px;
    }
    .impact.corticosteroids .damage .grid.first .pink-list li:last-child::before {
        top: 78px;
        right: 45%;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li p {
        font-size: 16px;
        line-height: 24px;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li::before {
        top: 56px;
        right: 35%;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li:nth-child(2):before {
        top: 52px;
        right: 8%;
    }
    .impact.corticosteroids .damage .grid .pink-list li:last-child::before {
        top: 52px;
        right: 41%;
    }
    .impact .damage .balance img {
        width: 85%;
    }
    .impact .damage .grey-box.mg-t {
        padding: 30px 35px 40px 30px;
        margin: 80px 0 90px;
    }
    .impact.corticosteroids .damage .grid.third .pink-list {
        margin-top: 0;
    }
    .impact.corticosteroids .damage .grid.third .pink-list li::before {
        top: 28px;
        right: 8%;
    }
    .impact.corticosteroids .damage .grid.third .grid-item .pink-list li:nth-child(2)::before {
        top: 54px;
        right: 64%;
    }
    .impact.corticosteroids .container-btn {
        padding: 50px 0 30px;
    }
    /* end Pagina Impacto Uso De Corticoides */
   .fisio .banner .title {
    padding: 160px 0 0;
}
.fisio.two .deregulation {
        margin-top: -510px;
    }

}
@media (max-width: 768px) {
    h1 {
        font-size: 45px;
        line-height: 50px;
    }
    h2 {
        font-size: 35px;
        line-height: 40px;
    }
    h3 {
        font-size: 30px;
        line-height: 38px;
    }
    h4 {
        font-size: 20px;
        line-height: 28px;
    }
    .banner {
        background-position-x: 0;
        height: 790px;
    }
    .banner .title {
        padding: 170px 0 13px;
    }
    .banner nav ul li, .about .grid .grid-item ul li {
        min-width: 100%;
    }
    .banner nav {
        width: fit-content;
    }
    .about {
        margin-top: 350px;
    }
    .about .grid .grid-item-box {
        max-width: 95%;
        padding: 40px 20px 20px 30px;
    }
    .about .grid .grid-item-box ul li {
        padding: 20px 20px 20px 60px;
        display: flex;
        flex-wrap: wrap;
        white-space: normal;
        word-break: break-word;
        overflow-wrap: break-word;
        text-align: left;
    }
    .badge::before {
        background-size: 37px;
        width: 37px;
        height: 37px;
        position: absolute;
        left: 10px;
    }
    .epdemiology .prevalence-box {
        padding: 30px 30px 50px 20px;
    }
    .epdemiology .values span {
        font-size: 54px;
    }
    .epdemiology .grid {
        grid-template-columns: 1fr;
        gap: 10px;
    }
    .epdemiology .prevalence-box:nth-child(4) {
        padding-right: 40px;
    }
    .scenario .grid.cards {
        grid-template-columns: 1fr;
    }
    .badge {
        padding: 20px 20px 20px 55px;
        min-width: 80%;
    }
    .badge-btn a {
        font-size: 16px;
    }
    .scenario .badge-btn a {
        display: inline-flex;
        text-align: center;
    }
    .scenario .container-btn {
        padding: 50px 0 0;
    }
    .footer {
        height: 480px;
    }
    .footer .grid {
        grid-template-columns: 1fr;
        gap: 20px;
        align-items: center;
        justify-content: center;
    }
    .footer img {
        max-width: 400px;
        margin: 0 auto;
    }
    .footer h4 {
        margin: 0 auto;
        text-align: center;
    }
    .ref-footer p {
        word-break: break-all;
    }

    /* Pagina Impacto Uso De Corticoides */
    .impact.corticosteroids .banner .title.different {
        padding: 150px 0 10px;
    }
    .impact .about.impact-cort .grid .grid-item-box {
        padding: 50px 20px 10px;
    }
    .impact.corticosteroids .illness {
        padding: 90px 0 70px;
    }
    .impact.corticosteroids .illness .yellow-box::before {
        top: 110px;
        right: 46%;
    }
    .impact .study {
        padding: 80px 0;
    }
    .impact .study .badge-title.purple {
        margin: 70px 0 30px;
    }
    .impact.corticosteroids .study .yellow-box::before {
        top: 82px;
        right: 49%;
    }
    .impact .risks {
        padding: 80px 0;
    }
    .impact.corticosteroids .risks h2 {
        font-size: 27px;
        line-height: 32px;
    }
    .impact.corticosteroids .risks .grey-box:nth-child(4) .img img {
        width: 1120.5px;
    }
    .impact.corticosteroids .risks .yellow-box::before {
        top: 81px;
        right: 26%;
    }
    .impact.corticosteroids .damage .yellow-box::before {
        top: 109px;
        right: 59%;
    }
    .impact.corticosteroids .damage .grid.first .pink-list li::before {
        top: 101px;
        right: 73px;
    }
    .impact.corticosteroids .damage .grid.first .pink-list li:last-child::before {
        top: 125px;
        right: 20%;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li::before {
        top: 101px;
        right: 62%;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li:nth-child(2):before {
        top: 101px;
        right: 13%;
    }
    .impact.corticosteroids .damage .grid .pink-list li:last-child::before {
        top: 102px;
        right: 70%;
    }
    .impact.corticosteroids .damage .grid.third .pink-list li::before {
        top: 52px;
        right: 6%;
    }
    .impact.corticosteroids .damage .grid.third .grid-item .pink-list li:nth-child(2)::before {
        top: 76px;
        right: 35%;
    }
    .impact .damage p.small {
        margin-bottom: 30px;
    }
    .impact.corticosteroids .container-btn {
        padding: 20px 0 10px;
    }
    .impact.corticosteroids .ref-footer {
        padding: 20px 0 70px;
    }
    /* end Pagina Impacto Uso De Corticoides */
    .diagnosis .banner .title {
        padding: 131px 0 0px;
    }
        .diagnosis .about.diagnosis-page.about .grid .grid-item-box {
        min-width: 100%;
        top: -325px;
        padding: 30px;
        border-radius: 40px;
    }
    .diagnosis .about.diagnosis-page.about .grid .grid-item-box .badge {
    gap: 10px;
    padding: 30px 35px 30px 70px;
    font-size: 16px;
}
.diagnosis .challenges {
        padding: 220px 0 20px;
    }
    .diagnosis .challenges .yellow-box {
    padding: 30px 30px 20px 40px;
    margin: 20px 0;
}
.diagnosis .challenges .yellow-box:before {
    display: none;
}
.diagnosis .ref-footer {
    padding: 30px;
}
    .footer {
        height: 470px;
    }
        .fisio.two .deregulation, .fisio.three .cytokines, .fisio.four .relevance, .fisio .about-fisio {
        margin-top: -360px;
        border-radius: 30px;
    }
    .container-btn {
        justify-content: center;
    }
    .fisio.three .cytokines .impact-list {
        padding: 60px 0 20px;
    }
        .impact .about.impact-het .grid .grid-item-box ul li p {
        line-height: 22px;
    }
    .impact .about.impact-het .grid .grid-item-box, .impact .about.impact-het .grid .grid-item {
        padding: 30px;
    }
        .impact .about.impact-het {
        margin-top: -400px;
        margin-bottom: 0px;
    }
    .impact .about .grid {
        gap: 0;
    }
     .impact .about .grid .grid-item img {
        display: block;
    }
    main.impact.corticosteroids .about {
        padding: 0;
    }
    .impact.corticosteroids .about.impact-cort {
        margin-top: -400px;
    }
    main.home .about {
    margin-top: -310px;
    padding: 0 0 50px;
}
 main.home .about .grid .grid-item-box {
        max-width: 100%;
        padding: 30px;
        border-radius: 30px;
    }
}

@media (max-width: 414px) { 
    h1 {
        font-size: 40px;
        line-height: 45px;
    }
    h2 {
        font-size: 32px;
        line-height: 38px;
    }
    h3 {
        font-size: 28px;
        line-height: 36px;
    }
    h4 {
        font-size: 18px;
        line-height: 25px;
    }
    .banner {
        height: 720px;
    }
    .about {
        padding: 70px 0 150px;
        margin-top: 320px;
    }
    .about .grid .grid-item-box p {
        margin-bottom: 20px;
    }
    .info-button {
        top: 70px;
    }
    .epdemiology {
        padding: 70px 0;
    }
    .epdemiology .prevalence-box {
        margin-top: 30px;
    }
    .epdemiology .values span {
        font-size: 50px;
    }
    .epdemiology .grid {
        gap: 0;
    }
    .ref-footer  {
        padding: 70px 0;
    }


    /* Pagina Impacto Uso De Corticoides */
    .impact.corticosteroids     .banner {
        height: 755px;
    }
    .impact.corticosteroids .illness {
        padding: 50px 0;
    }
    .impact.corticosteroids .illness .yellow-box::before {
        top: 110px;
        right: 34%;
    }
    .impact .study {
        padding: 70px 0;
    }
    .impact .study .badge-title.purple {
        margin: 50px 0 30px;
    }
    .impact .study .yellow-box {
        padding-right: 20px;
        margin: 40px 0 50px;
    }
    .impact.corticosteroids .study .yellow-box::before {
        right: 26%;
    }
    .impact.corticosteroids .risks h2 {
        font-size: 25px;
        line-height: 32px;
    }
    .impact.corticosteroids .risks .yellow-box {
        padding: 30px 20px 20px;
        font-size: 16px;
        line-height: 24px;
    }
    .impact.corticosteroids .risks .yellow-box::before {
        top: 78px;
        right: 36%;
    }
    .impact.corticosteroids .damage .yellow-box::before {
        top: 109px;
        right: 21%;
    }
    .pink-list li p {
        font-size: 14px;
        line-height: 22px;
    }
    .pink-list li::before {
        width: 16px;
        height: 16px;
        background-size: 16px;
    }
    .impact.corticosteroids .damage .grid.first .pink-list li::before {
        top: 96px;
        right: 69px;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li::before {
        top: 103px;
        right: 49%;
    }
    .impact.corticosteroids .damage .grid.second .pink-list li:nth-child(2):before {
        top: 128px;
        right: 29%;
    }
    .impact.corticosteroids .damage .grid .pink-list li:last-child::before {
        top: 102px;
        right: 52%;
    }
    .impact .damage .balance img {
        width: 100%;
    }
    /* end Pagina Impacto Uso De Corticoides */
    
}

@media (max-width: 380px) { 
    h2 {
        font-size: 30px;
        line-height: 36px;
    }
    h3 {
        font-size: 24px;
        line-height: 36px;
    }
    h4 {
        font-size: 16px;
        line-height: 22px;
    }
   
}