@font-face {
    font-display: swap;
    font-family: Helvetica Neue LT Pro extend;
    font-style: normal;
    src: local("Helvetica-Neue"),url(../fonts/Linotype\ -\ HelveticaNeueLTPro-BlkEx.otf) format("opentype")
}
@font-face {
    font-display: swap;
    font-family: Helvetica Neue LT Pro light extend;
    font-style: normal;
    src: local("Helvetica-Neue"),url(../fonts/Helvetica\ Neue\ LT\ Pro\ 43\ Light\ Extended.otf) format("opentype")
}
@font-face {
    font-display: swap;
    font-family: Helvetica LT Pro;
    font-style: normal;
    src: local("Helvetica-Neue"),url(../fonts/HelveticaNeueLTPro-Bd.ttf) format("opentype")
}
html {
    height: 100%;
}
/* General */
body {
    font-family: "Inter", sans-serif;
    font-size: 18px;
    line-height: 28px;
    color: #121C28;
    background-color: #ffffff;
    font-weight: 500;
    font-style: normal;
    box-sizing: border-box;
    margin: 0;
}

ul {
    padding: 0;
}

ul li {
    list-style: none;
}

img {
    width: 100%;
}

h1 {
    text-transform: uppercase;
    font-size: 65px;
    line-height: 70px;
    font-weight: 400;
    margin-bottom: 30px;
    color: #ffffff;
    font-family: Helvetica Neue LT Pro light extend;
}
h1 span, h1 strong, h2 strong, h3 span, h3 strong {
    font-family: Helvetica Neue LT Pro extend;
}

h2 {
    text-transform: uppercase;
    font-size: 60px;
    line-height: 55px;
    font-weight: 400;
    margin-bottom: 30px;
    color: #6B3223;
    font-family: Helvetica LT Pro;
}

h3 {
    text-transform: uppercase;
    color: #A15F4F;
    font-size: 45px;
    line-height: 52px;
    font-family: Helvetica Neue LT Pro light extend;
    margin-bottom: 30px;
}

h4 {
    font-family: "Inter", sans-serif;
    font-size: 22px;
    line-height: 26px;
    color: #ffffff;
    font-weight: 700;
    margin-bottom: 30px;
}

p {
    font-size: 16px;
    line-height: 24px;
    font-weight: 400;
    margin-bottom: 10px;
}

.small {
    font-size: 12px;
    line-height: 20px;
    color: #454545;
}

.medium {
    font-size: 14px;
}

.large {
    font-size: 18px;
    line-height: 26px;
}

.grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 90px;
}

.bg-light-brown {
    background-color: #FDF6F4;
}
.bg-orange {
    background-color: #FFF9EF;
}

.pd-t {
    padding-top: 100px;
}


/* Section banner */
.banner {
    position: relative;
    background: url(../img/banner.png) top right/cover no-repeat;
    width: 100%;
    height: 1160px;
    padding: 130px 0 0;
    z-index: 99;
}
.banner .title {
    display: flex;
    flex-direction: column;
    align-items: flex-start;
    padding: 230px 0 100px;
    position: relative;
    z-index: 99;
}
.banner .title p {
    font-size: 18px;
    line-height: 26px;
    color: #ffffff;
}
.banner nav {
    width: 1320px;
    padding: 20px 10px 20px 120px;
    background-color: #ffffff;
    max-width: 1320px;
    border-radius: 20px; 
    box-shadow: 0 0 20px rgba(190, 190, 190, 0.25); 
    margin-left: -70px;
}
.banner nav .navbar-nav .nav-link {
    color: #374151;
    z-index: 9999;
    position: relative;
    cursor: pointer;
    padding: .5rem 30px;
}
.banner nav .navbar-nav .nav-link strong {
    color: #A15F4F;
}
/* end Section banner */

/* Section about */
.about {
    padding: 350px 0 90px;
    margin-top: -430px;
    margin-bottom: -20px;
}
.about .grid {
    align-items: center;
    grid-template-columns: 1.2fr 1fr;
    gap: 0;
}
.about .grid .grid-item {
    display: flex;
    flex-direction: column;
    align-items: flex-end;
    gap: 20px;
}
.box-brown {
    padding: 20px 50px 40px 40px;
    background-color: #6B3223;
    border-radius: 20px;
    display: flex;
    flex-direction: column;
    align-items: center;
}
.about .box-brown img {
    max-width: 305px;
}
.about .box-brown h4, .about .box-brown p  {
    text-align: center;
    color: #ffffff;
    max-width: 300px;
}
.about .grid.two {
    grid-template-columns: 1fr 1fr;
    gap: 20px;
    margin-top: 50px;
}
.about .grid.two .box-white {
    padding: 50px 30px;
    background-color: #ffffff;
    border-radius: 20px;
    border: 1px solid #D4D4D4;
    display: flex;
}
.about .grid.two .box-white img {
    max-width: 203px;
    max-height: 123px;
}
.about .grid.two .box-white:first-child p {
    max-width: 355px;
}
.about .grid.two .box-white:last-child {
    gap: 20px;
}
.about .grid.two .box-white:last-child p.medium {
    min-height: 96px;
}
.about .box-brown-two {
    padding: 60px 120px;
    background-color: #A15F4F;
    border-radius: 16px;
    box-shadow: 0px 4px 40px rgba(143, 143, 143, 0.25);
    margin: 80px auto 0;
}
.about .box-brown-two p {
    max-width: 828px;
    text-align: center;
    color: #FFFFFF;
    margin: 0 auto;
}
/* end Section about */

/* Section epidemiology */
.epidemiology {
    padding: 180px 0;
    position: relative;
}
.epidemiology p {
    max-width: 528px;
}
.epidemiology .grid {
    padding: 100px 0 0;
}
.epidemiology .grid p {
    max-width: 320px;
}
.epidemiology .box-img {
    background-color: #FFFFFf;
    padding: 20px;
    border-radius: 24px;
    position: relative;
    margin-top: 20px;
    position: relative;
    z-index: 99;
}
.epidemiology .detail-one {
    width: 1164px;
    left: 0;
    top: 0;
    position: absolute;
}
/* end Section epidemiology */

/* Section factors */
.factors {
    padding: 60px 0 200px;
    margin-bottom: -40px;
}
.factors .factors-content{
    padding: 80px 0;
}
.factors .factors-content .box-two-colors {
    max-width: 446px;
    display: flex;
    flex-direction: column;
    align-items: center;
}
.factors .factors-content .box-two-colors .box-title {
    width: 100%;
    padding: 20px 50px 10px;
    background-color: #6B3223;
    color: #FFFFFf;
    border-radius: 8px 8px 0 0;
    text-align: center;
}
.factors .factors-content .box-two-colors .box-title p {
    font-size: 20px;
}
.factors .factors-content .box-two-colors .box-content {
    width: 100%;
    padding: 20px 70px;
    color: #656565;
    background-color: #FFFFFf;
    border-radius: 0 0 8px 8px;
}
.factors .factors-content .box-two-colors .box-content ul {
    min-height: 100px;
}
.factors .factors-content .box-two-colors:last-child .box-content ul {
    min-height: 140px;
}
.factors .factors-content .box-two-colors .box-content ul li {
    list-style: disc;
    font-size: 18px;
}
.factors .factors-content .box-two-colors .box-content ul li::marker {
    color: #6B3223;
}
.factors .factors-content .box-two-colors.warning {
    margin-left: 200px;
}
.factors .factors-content .box-two-colors.warning ul {
    min-height: max-content;
    padding-left: 80px;
    margin-bottom: 0;
}
.factors .factors-content .box-two-colors.warning ul li {
    position: relative;
}
.factors .factors-content .box-two-colors.warning ul li::before {
    content: '';
    width: 120px;
    height: 120px;
    background-color: #FFFFFF;
    border-radius: 50%;
    background-image: url(../img/exclamation.svg);
    background-size: 62px;
    background-repeat: no-repeat;
    background-position: center;
    position: absolute;
    top: -138px;
    left: -205px;
    transform: translateY(50%);
    border: 4px solid #FFFFFF;
}
.factors .factors-content .grid.first {
    grid-template-columns: 2fr 1fr;
    gap: 12px;
    margin-top: 20px;
}
.factors .factors-content .grid .grid.second {
    grid-template-columns: 1fr 1fr;
    gap: 10px;
}
.factors .factors-content .grid .box-brown-three {
    background-color: #6B3223;
    color: #FFFFFF;
    padding: 90px 40px 80px 60px;
    border-radius: 8px 80px 8px 100px;
}
.factors .factors-content .grid .box-brown-three p {
    max-width: 308px;
    font-size: 22px;
    line-height: 32px;
}
/* end Section factors */

/* Section factors-two */
.factors-two {
    padding: 100px 0 0;
    background-color: #6B3223;
    margin: -10px 0;
}
.factors-two .grid {
    grid-template-columns: 1.5fr 1fr;
}
.factors-two .grid .grid-item p {
    font-size: 20px;
    line-height: 26px;
    max-width: 600px;
    color: #FFFFFF;
}
.factors-two .grid .grid-item ul {
    padding-top: 40px;
}
.factors-two .grid .grid-item ul li {
    padding: 20px 70px;
    background-color: #FDF6F4;
    border-radius: 10px;
    margin-bottom: 10px;
    position: relative;
}
.factors-two .grid .grid-item ul li::before, .signs .signs-box-one .grid ul li::before {
    content: '';
    width: 10px;
    height: 10px;
    background-color: #D7A093;
    border-radius: 50%;
    position: absolute;
    top: 33px;
    left: 40px;
    transform: translateY(-50%);
}
.factors-two .grid .grid-item img {
    margin-top: -200px;
    position: relative;
    z-index: 99;
}
/* end Section factors-two */

/* end Section etiology */
.etiology {
    padding: 30px 0 100px;
}
.etiology p {
    max-width: 561px;
    padding-top: 50px;
}
.etiology .box-image {
    padding: 80px 40px;
    background-color: #FFFFFF;
    border: 1px solid #D5D5D5;
    border-radius: 23px;
    margin-top: 30px;
}
/* end Section etiology */

/* Section mechanism */
.mechanism {
    padding: 90px 0;
}
.mechanism .img {
    padding: 50px 60px;
}
.mechanism .img img {
    max-width: 1040px;
}
/* end Section mechanism */

/* Section therapies */
.therapies {
    padding: 90px 0 30px;
}
.therapies .img {
    padding: 40px 0;
}
/* end Section therapies */

/* Section signs */
.signs {
    padding: 80px 0;
}
.signs .signs-box-one {
    padding: 80px 100px 60px;
    background-color: #F8E9E5;
    border-radius: 10px 80px 10px 100px;
}
.signs .signs-box-one .grid {
    grid-template-columns: 1fr 2fr;
    align-items: center;
}
.signs .signs-box-one .grid p {
    max-width: 592px;
}
.signs .signs-box-one .grid ul {
    display: grid;
    grid-template-columns: 1fr 1fr;
    column-gap: 7px;
    row-gap: 5px;
    margin-top: 30px;
}
.signs .signs-box-one .grid ul li {
    padding: 20px 60px;
    background-color: #6B3223;
    color: #FFFFFF;
    border-radius: 12px;
    max-height: max-content;
    position: relative;
}
.signs .signs-box-one.grey {
    background-color: #F4F4F4;
    border-radius: 60px 10px 80px 10px;
    margin-top: 30px;
}
.signs .signs-box-one.grey p {
    max-width: 500px;
}
.signs .signs-box-one.grey img {
    max-width: 209px;
}
.signs .signs-box-one.grey .grid .grid-item:first-child {
    margin:  0 auto;
}
/* end Section signs */

/* Section diagnosis */
.diagnosis {
    padding: 90px 0;
}
.diagnosis .diagnosis-box {
    padding: 80px 70px;
    background-color: #F8E9E5;
    border-radius: 15px;
    margin: 60px 0 20px;
}
.diagnosis .diagnosis-box.smooth {
    background-color: #FDF6F4;
    margin-top: 0;
    padding-right: 50px;
}
.diagnosis .diagnosis-box.smooth .grid {
    gap: 45px;
}
.diagnosis .diagnosis-box.smooth .grid .grid-item:first-child p {
    min-width: 575px;
}
/* end Section diagosis */

/* Section subtypes */
.subtypes {
    padding: 50px 0;
}
.subtypes h2 {
    margin-bottom: 60px;
}
.subtypes .grid {
    grid-template-columns: 1fr 1fr 1fr;
    gap: 8px;
    margin-bottom: 100px;
}
.subtypes .grid .grid-box {
    padding: 80px 60px 60px 50px;
    background-color: #F2F2F2;
    color: #000;
    border-radius: 8px;
}
.subtypes .grid .grid-box.dark {
    background-color: #A15F4F;
    color: #FFFFFF;
    border-bottom-left-radius: 62px;
}
.subtypes .grid .grid-box.dark h4 {
    color: #FFFFFF;
}
.subtypes .grid .grid-box:last-child {
    border-top-right-radius: 62px;
}
.subtypes .grid .grid-box h4 {
    color: #000;
}
.subtypes .grid .grid-box p {
    max-width: 327px;
}
.subtypes .subtypes-content {
    padding: 0 120px;
}
.subtypes .subtypes-content .subtypes-content-box {
    padding: 70px 120px 50px;
    border-radius: 8px;
    background-color: #F8E9E5;
    margin-bottom: 20px;
}
.subtypes .subtypes-content .subtypes-content-box:last-child h4 {
    font-size: 24px;
    line-height: 32px;
    margin-bottom: 20px;
    color: #000;
}
.subtypes .subtypes-content .subtypes-content-box:first-child {
    background-color: #A15F4F;
    color: #FFFFFF;
    display: flex;
    gap: 90px;
    align-items: center;
}
.subtypes .subtypes-content .subtypes-content-box:first-child h4 {
    font-size: 32px;
    line-height: 39px;
    margin-bottom: 0;
}
.subtypes .subtypes-content .subtypes-content-box:first-child p {
    max-width: 419px;
}
/* end Section subtypes */

/* Section warnings */
.warnings {
    padding: 120px 0 0;

}
.warnings .box-warnings .box-warnings-title {
    background-color: #6B3223;
    color: #ffffff;
    padding: 30px 0 20px 40px;
    border-radius: 6px 6px 0 0;
}
.warnings .box-warnings .box-warnings-title h6 {
    font-size: 1.125rem;
    font-family: "Inter", sans-serif;
}
.warnings .box-warnings .box-warnings-content {
    background-color: #FDF6F4;
    color: #374151;
    border-radius: 0 0 6px 6px; 
    padding: 10px 40px 10px;
}
.warnings .box-warnings .box-warnings-content ul {
    padding-right: 50px;
    margin: 0;
}
.warnings .box-warnings .box-warnings-content ul li {
    list-style: none;
    padding: 30px 0 30px 40px;
    margin-bottom: 0;
    position: relative;
    border-bottom: 1px dashed #CACACA;
}
.warnings .box-warnings .box-warnings-content ul li:last-child {
    border-bottom: none;
}
.warnings .box-warnings .box-warnings-content ul li a {
    color: #6B3223;
    font-weight: bold;
    text-decoration: none;
}
.warnings .box-warnings .box-warnings-content ul li:last-child a {
    text-decoration: underline;
}
.warnings .box-warnings .box-warnings-content ul li::after {
    content: '';
    position: absolute;
    width: 11px;
    height: 16px;
    background-size: 12px;
    background-repeat: no-repeat;
    right: 47%;
    top: 42%;
    transform: translateX(-50%);
    background-image: url(../img/lock.svg);
}
.warnings .box-warnings .box-warnings-content ul li:first-child::after {
    right: 48%;
}
.warnings .box-warnings .box-warnings-content ul li:last-child::after {
    display: none;
}
.warnings .box-warnings .box-warnings-content ul li:before {
    content: '';
    position: absolute;
    width: 32px;
    height: 32px;
    background-size: 20px;
    background-repeat: no-repeat;
    left: 6px;
    top: 58%;
    transform: translateY(-50%);
    background-image: url(../img/excla.svg);
}
/* end Section warnings */


/* Section ref-footer */
.ref-footer {
    padding: 90px 0;
}
.ref-footer p:first-child {
    font-size: 14px;
    line-height: 26px;
}
.ref-footer p {
    font-size: 12px;
    line-height: 20px;
    margin-bottom: 0;
}
/* end Section ref-footer */

/* Responsive */
@media (max-width: 1800px) {
    .banner {
        height: 1110px;
        padding: 60px 0 0;
    }
    .banner nav {
        width: 1220px;
        padding: 20px 10px 20px 80px;
        margin-left: -50px;
    }
    .about {
        padding: 300px 0 90px;
        margin-top: -485px;
    }
}
@media (max-width: 1540px) {
    .banner {
        height: 855px;
    }
    .banner .title {
        padding: 140px 0 100px;
    }
    .banner .title h1 {
        font-size: 60px;
        line-height: 65px;
    }
    .banner nav {
        padding: 20px 10px 20px 30px;
        width: 100%;
        margin-left: 0;
    }
    .about {
        padding: 250px 0 90px;
        margin-top: -240px;
    }
    h2 {
        font-size: 55px;
        line-height: 50px;
    }
    h3 {
        font-size: 40px;
        line-height: 47px;
    }
}

@media (max-width: 1200px) {
    .banner .title h1 {
        font-size: 55px;
        line-height: 60px;
    }
    h2 {
        font-size: 50px;
        line-height: 45px;
    }
    h3 {
        font-size: 34px;
        line-height: 40px;
    }
    .banner {
        height: 690px;
    }
    .banner .title {
        padding: 120px 0 70px;
    }
    .banner nav .navbar-nav .nav-link {
        padding: .5rem 15px;
    }
    .about {
        margin-top: -270px;
        margin-bottom: -6px;
    }
    .about .grid.two .box-white {
        padding: 50px 20px 30px;
    }
    .about .grid.two .box-white img {
        max-width: 150px;
        max-height: 94px;
    }
    .about .box-brown-two {
        padding: 60px;
    }
    .factors .factors-content .grid.first {
        grid-template-columns: 1.5fr 1fr;
    }
    .factors .factors-content .grid .grid.second {
        grid-template-columns: 1fr;
        margin: 0 auto;
    }
    .factors .factors-content .grid .box-brown-three {
        height: max-content;
    }
    .factors-two {
        padding: 70px 0 0;
    }
    .factors-two .grid .grid-item img {
        margin-top: -110px;
    }
    .signs .signs-box-one .grid ul li {
        padding: 20px 10px 20px 40px;
        font-size: 16px;
        line-height: 20px;
    }
    .signs .signs-box-one .grid ul li::before {
        left: 20px;
    }
    .diagnosis .diagnosis-box.smooth .grid .grid-item:first-child p {
        min-width: 100%;
    }
    .subtypes .subtypes-content {
        padding: 0 60px;
    }
    .subtypes .subtypes-content .subtypes-content-box {
        padding: 70px 80px 50px;
    }
    .warnings .box-warnings .box-warnings-content ul li::after {
        right: 23%;
    }
    .warnings .box-warnings .box-warnings-content ul li:first-child::after {
        right: 24%;
    }
        
}

@media (max-width: 991px) {
    h2 {
        font-size: 45px;
        line-height: 50px;
    }
    h3 {
        font-size: 30px;
        line-height: 36px;
    }
    .grid {
        grid-template-columns: 1fr;
        gap: 30px;
    }
    .img img, .grid-img img {
        max-width: none!important;
        width: unset;
    }
    .img, .grid-img {
        width: 100%;
        overflow: auto;
    }
    .banner .title h1 {
        font-size: 40px;
        line-height: 45px;
    }
    .banner {
        height: 520px;
    }
    .banner .title {
        padding: 50px 0 60px;
    }
    .banner nav {
        padding: 20px;
        width: max-content;
    }
    .about .grid {
        grid-template-columns: 1fr;
        gap: 10px;
    }
    .about .grid .grid-item {
        align-items: flex-start;
    }
    .about .grid .grid-item:last-child {
        align-items: center;
    }
    .about .grid.two {
        grid-template-columns: 1fr;
    }
    .about .grid.two .box-white {
        padding: 50px 90px 30px;
    }
    .image {
        padding: 50px 0 0;
    }
    .epidemiology .grid {
        grid-template-columns: 1fr 1fr;
    }
    .factors .factors-content .grid.first {
        grid-template-columns: 1fr;
    }
    .factors .factors-content .grid .grid.second {
        margin: 0;
    }
    .factors .factors-content .box-two-colors {
        max-width: 100%;
    }
    .factors .factors-content .box-two-colors .box-content ul, .factors .factors-content .box-two-colors:last-child .box-content ul {
        min-height: max-content;
    }
    .factors .factors-content .grid .box-brown-three p {
        max-width: 100%;
    }
    .factors-two .grid {
        grid-template-columns: 1fr;
    }
    .factors-two .grid .grid-item img {
        margin-top: 0;
        padding-bottom: 50px;
    }
    .etiology {
        padding: 90px 0;
    }
    .etiology p {
        padding-top: 20px;
    }
    .mechanism {
        padding: 20px 0;
    }
    .therapies {
        padding: 90px 0 70px;
    }
    .signs .signs-box-one .grid ul {
        grid-template-columns: 1fr;
    }
    .diagnosis {
        padding: 50px 0;
    }
    .subtypes .grid {
        grid-template-columns: 1fr;
    }
    .subtypes .grid .grid-box.dark {
        border-bottom-left-radius: 8px;
    }
    .subtypes .grid .grid-box:last-child {
        border-top-right-radius: 8px;
    }
    .subtypes .subtypes-content .subtypes-content-box:first-child {
        display: block;
    }
    .warnings {
        padding: 70px 0 0;
    }
    .warnings .box-warnings .box-warnings-content ul li:first-child::after {
        right: 2%;
    }
    .warnings .box-warnings .box-warnings-content ul li::after {
        right: -1%;
    }
    .warnings .box-warnings .box-warnings-content ul {
        padding-right: 0;
    }
    .warnings .box-warnings .box-warnings-content ul li:last-child a {
        word-break: break-all;
    }
    .navbar-toggler {
        border-color: #A15F4F;
        padding: 14px;
    }
    .navbar-toggler .content {
        display: flex;
        flex-direction: column;
        justify-content: space-between;
        height: 24px;
        width: 30px;
    }
    .navbar-toggler .content span {
        display: block;
        height: 3px;
        width: 100%;
        background-color: #A15F4F;
        border-radius: 2px;
        transition: all 0.3s ease;
    }
   
}
@media (max-width: 768px) {
    h1 {
        font-size: 40px;
        line-height: 40px;
    }
    h2 {
        font-size: 35px;
        line-height: 45px;
    }
    h3 {
        font-size: 25px;
        line-height: 30px;
    }
    .banner {
        height: 700px;
        background: url(../img/banner.png) top left / cover no-repeat;
    }
    .banner .title {
        padding: 70px 0 80px;
    }
    .about {
        margin-top: -320px;
    }
    .about .grid.two .box-white {
        padding: 50px 50px 30px;
        display: block;
    }
    .about .grid.two .box-white img {
        margin-bottom: 20px;
    }
    .about .box-brown-two {
        padding: 60px 30px;
        margin: 50px auto 0;
    }
    .epidemiology {
        padding: 120px 0;
    }
    .epidemiology .detail-one {
        display: none;
    }
    .epidemiology .grid {
        grid-template-columns: 1fr;
        padding: 50px 0;
    }
    .factors {
        padding: 60px 0 100px;
    }
    .factors .factors-content {
        padding: 20px 0 50px;
    }
    .factors .factors-content .box-two-colors.warning {
        margin-left: 25px;
    }
    .factors .factors-content .box-two-colors.warning ul li::before {
        left: -180px;
    }
    .therapies h3 br {
        display: none;
    }
    .signs .signs-box-one {
        padding: 80px 50px 60px;
    }
    .signs .signs-box-one .grid {
        grid-template-columns: 1fr;
    }
    .diagnosis {
        padding: 20px 0 30px;
    }
    .diagnosis .diagnosis-box {
        padding: 80px 40px;
    }
    .subtypes h2 {
        margin-bottom: 30px;
    }
    .subtypes .grid .grid-box {
        padding: 80px 40px 60px 50px;
    }
    .subtypes .subtypes-content {
        padding: 0;
    }
    .subtypes .subtypes-content .subtypes-content-box {
        padding: 70px 30px 50px;
    }
    .warnings {
        padding: 20px 0 0;
    }
    .warnings .box-warnings .box-warnings-content {
        padding-left: 20px;
    }
    .warnings .box-warnings .box-warnings-content ul {
        padding-right: 0;
    }
    .warnings .box-warnings .box-warnings-content ul li {
        padding: 20px 0 20px 40px;
    }
    .warnings .box-warnings .box-warnings-content ul li::after {
        top: 57%;
    }
    .ref-footer {
        padding: 120px 0 60px;
    }
    .ref-footer p {
        word-break: break-word;
    }
}
@media (max-width: 414px) {
    h2 {
        font-size: 30px;
        line-height: 28px;
    }
    h3 {
        font-size: 20px;
        line-height: 20px;
    }
    h4 {
        font-size: 20px;
        line-height: 24px;
    }
    .large {
        font-size: 16px;
        line-height: 24px;
    }
    .banner {
        height: 590px;
        padding: 0; 
    }
    .banner .title {
        padding: 80px 0 30px;
    }
    .epidemiology {
        padding: 90px 0;
    }
    .factors .factors-content .box-two-colors.warning ul {
        padding-left: 38px;
    }
    .factors .factors-content .box-two-colors.warning ul li::before {
        width: 100px;
        height: 100px;
        background-size: 52px;
        top: -120px;
        left: -130px;
    }
    .factors-two {
        margin: 0;
    }
    .factors-two .grid .grid-item ul li {
        padding: 20px 55px 20px 70px;
    }
    .etiology h3 br {
        display: none;
    }
    .mechanism h3, .therapies h3 {
        font-family: 'Helvetica Neue LT Pro extend';
        line-height: 1.2;
    }
    .subtypes .grid .grid-box {
        padding: 80px 30px 60px 40px;
    }
    .subtypes .subtypes-content .subtypes-content-box:first-child h4 {
        font-size: 20px;
        line-height: 20px;
        margin-bottom: 20px;
    }
    .subtypes .subtypes-content .subtypes-content-box:last-child h4 {
        font-size: 20px;
        line-height: 20px;
        margin-bottom: 20px;
    }
    .warnings .box-warnings .box-warnings-content {
        padding: 10px 20px 10px;
    }
    .warnings .box-warnings {
        width: auto;
        max-width: 94%;
    }
    .warnings .box-warnings .box-warnings-content ul {
        padding-right: 0;
    }
    .warnings .box-warnings .box-warnings-content ul li {
        font-size: 16px;
        line-height: 26px;
    }
    .warnings .box-warnings .box-warnings-content ul li::after {
        display: none;
    }
    .ref-footer {
        padding: 90px 0 60px;
    }
}