@font-face {
    font-display: swap;
    font-family: Helvetica Neue LT Pro extend;
    font-style: normal;
    src: local("Helvetica-Neue"),url(../fonts/Linotype\ -\ HelveticaNeueLTPro-BlkEx.otf) format("opentype")
}
@font-face {
    font-display: swap;
    font-family: Helvetica Neue LT Pro light extend;
    font-style: normal;
    src: local("Helvetica-Neue"),url(../fonts/Helvetica\ Neue\ LT\ Pro\ 43\ Light\ Extended.otf) format("opentype")
}
html {
    height: 100%;
}
/* General */
body {
    font-family: "Inter", sans-serif;
    font-size: 18px;
    line-height: 28px;
    color: #121C28;
    background-color: #F5F5F5;
    font-weight: 500;
    font-style: normal;
    box-sizing: border-box;
    margin: 0;
}

ul {
    padding: 0;
}

ul li {
    list-style: none;
}

img {
    width: 100%;
}

h1 {
    text-transform: uppercase;
    font-size: 60px;
    line-height: 65px;
    font-weight: bold;
    margin-bottom: 30px;
    color: #fff;
}

h2 {
    text-transform: uppercase;
    font-size: 45px;
    line-height: 50px;
    font-weight: bold;
    margin-bottom: 30px;
    color: #2552BE;
    font-family: Helvetica Neue LT Pro extend;
}

h3 {
    text-transform: uppercase;
    color: #2552BE;
    font-size: 30px;
    line-height: 30px;
    font-family: Helvetica Neue LT Pro light extend;
    margin-bottom: 30px;
}
h3 span, h3 strong {
    font-family: Helvetica Neue LT Pro extend;
}

h4 {
    color: var(--color-neutral-900);
    font-weight: bold;
    line-height: 32px;
}

p {
    font-size: 16px;
    font-weight: 400;
    margin-bottom: 10px;
}

.small {
    font-size: 12px;
    line-height: 26px;
}

/* form */
.banner {
    position: relative;
    background: url(../img/prostata/banner.png) top left/cover no-repeat;
    width: 100%;
    height: 890px;
    padding: 50px 0 70px;
}
/* .banner::before {
    content: '';
    position: absolute;
    background: url(../img/pessoa.png);
    background-repeat: no-repeat;
    width: 828px;
    background-size: 828px;
    height: 1200px;
    top: -160px;
    right: 0;
    z-index: 9;
} */
.banner .title {
    padding: 200px 0 100px;
}
.banner .title img {
    width: 420px;
    margin-bottom: 30px;
}
.banner .title h2 {
    font-size: 50px;
    line-height: 55px;
    color: #ffffff;
}
.banner .title p {
    font-size: 26px;
    line-height: 34px;
    color: #fff;
}
.banner nav {
    padding: 20px 40px;
    background-color: #ffffff;
    border-radius: 6px; 
    box-shadow: 0 0 20px rgba(190, 190, 190, 0.25); 
}
.banner nav .navbar-nav .nav-link {
    color: #374151;
    z-index: 9999;
    position: relative;
    cursor: pointer;
    padding: .5rem 30px;
}
.banner nav .navbar-nav .nav-link strong {
    color: #2552BE;
}
.epidemiology {
    position: relative;
}
.epidemiology::before {
    content: '';
    position: absolute;
    background-image: url(../img/prostata/bg-epide.svg);
    background-repeat: no-repeat;
    width: 686px;
    height: 1084px;
    right: 0;
    top: 280px;
    z-index: -1;
}
.epidemiology .epidemiology-box {
    position: relative;
    background-color: #ffffff;
    padding: 70px 140px;
    border-radius: 10px;
    box-shadow: 0 4px 50px rgba(206, 206, 206, 0.25); 
    max-width: 1180px;
    margin: 0 auto;
}
.epidemiology .epidemiology-box::before {
    content: '';
    position: absolute;
    background-image: url(../img/prostata/ball02.svg);
    background-repeat: no-repeat;
    width: 255px;
    height: 298px;
    right: -160px;
    top: -45px;
    z-index: -1;
}
.epidemiology .epidemiology-box::after {
    content: '';
    position: absolute;
    background-image: url(../img/prostata/ball01.svg);
    background-repeat: no-repeat;
    width: 240px;
    height: 296px;
    left: -130px;
    top: -90px;
    z-index: -1;
}
.epidemiology .title {
    padding-top: 100px;
}
.epidemiology .grid {
    padding: 50px 0;
    display: flex;
    align-items: center;
    gap: 90px;
}
.epidemiology .grid .grid-item:last-child {
    padding-top: 30px;
}
.epidemiology .grid .grid-item p {
    margin-top: 40px;
}
.epidemiology .grid .grid-item p.small.two  {
    margin-top: 80px;
    text-align: right;
}
.brazil {
    padding: 90px 0;
}
.brazil .grid {
    position: relative;
    padding: 20px 0px 120px 50px;
}
.brazil .grid::before {
    content: '';
    position: absolute;
    width: 25px;
    height: 310px;
    left: 0;
    top: 25px;
    background-image: url(../img/prostata/borda-logo-2.svg);
    background-repeat: no-repeat;
}
.brazil .grid .item {
    display: flex;
    align-items: center;
    gap: 50px;
}
.brazil .grid .item {
    background-color: #ffffff;
    border-radius: 10px;
    border: 1px solid #EAEEF1; 
    box-shadow: 0 4px 50px rgba(206, 206, 206, 0.25); 
    padding: 30px 30px;
    margin-bottom: 20px;
    max-width: 650px;
}
.brazil .grid .item p {
    margin-bottom: 0;
}
.brazil .brazil-container {
    margin: 0 80px;
}
.brazil .img {
    position: relative;
}
.brazil .img .small {
    position: absolute;
    max-width: 537px;
    bottom: -50px;
}
.brazil .brazil-box {
    position: relative;
    margin: 180px 0 0;
    background-color: #0A69FA;
    padding: 50px 140px 60px;
    border-radius: 28px;
    box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    position: relative;
}
.brazil .brazil-box::after {
    content: '';
    position: absolute;
    background-image: url(../img/prostata/ball01.svg);
    background-repeat: no-repeat;
    width: 240px;
    height: 296px;
    left: -130px;
    top: -90px;
    z-index: -1;
}
.brazil .brazil-box img {
    position: absolute;
    bottom: 0;
    left: 0;
}
.brazil .brazil-box p {
    max-width: 912px;
    font-size: 22px;
    line-height: 32px;
    font-weight: 400;
    color: #ffffff;
}
.clinical-phases {
    padding: 70px 0;
}
.clinical-phases h3 {
    margin: 40px 0 30px;
}
.signs {
    padding: 90px 0 100px;
    background-color: #EDF3FF;
}
.signs p {
    max-width: 833px;
}
.signs .signs-row {
    display: flex;
    align-items: center;
    gap: 10px;
    padding: 70px 0;
}
.signs .signs-row .signs-box-item {
    background-color: #ffffff;
    padding: 30px 20px 20px;
    min-width: 254px;
    min-height: 284px;
    border-radius: 12.85px;
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: space-around;
    gap: 20px;
}
.signs .signs-row .signs-box-item img  {
    max-width: 94px;
    max-height: 122px;
}
.signs .signs-row .signs-box-item:nth-child(2) img {
    max-width: 54px;
}
.signs .signs-row .signs-box-item:nth-child(3) img {
    max-width: 68px;
}
.signs .signs-row .signs-box-item p {
    text-align: center;
    line-height: 20px;
}
.signs h3 {
    font-size: 45px;
    line-height: 50px;
}
.diagnosis {
    position: relative;
    background-color: #ffffff;
    padding: 90px 0 30px;
}
.diagnosis .grid {
    display: grid;
    grid-template-columns: 2fr 1fr;
    gap: 20px;
    align-items: center;
    padding: 20px 0;
}
.diagnosis .grid .diagnosis-item ul{
    margin-bottom: 0;
}
.diagnosis .grid .diagnosis-item ul li {
    padding: 40px 50px 30px;
    background-color: white;
    border-radius: 10px;
    border: 1px solid #F1EAF0;
    box-shadow: 0 4px 50px rgba(206, 206, 206, 0.25);
    margin-bottom: 20px;
}
.diagnosis .grid .diagnosis-item ul li:last-child {
    margin-bottom: 0;
}
.diagnosis .grid .diagnosis-item ul li h3 {
    margin-bottom: 20px;
}
.diagnosis .grid .diagnosis-item ul li p {
    line-height: 20px;
    margin-bottom: 10px;
}
.diagnosis .grid .diagnosis-item img {
    max-width: 382px;
}
.confirmation {
    padding: 70px 0;
}
.confirmation h3 {
    margin-bottom: 10px;
}
.confirmation ul li {
    list-style: disc;
}
.confirmation ul {
    padding: 0 30px;
}
.confirmation .img {
    padding: 30px 0;
    margin: 0 auto;text-align: center;
}
.confirmation .img img {
    max-width: 750px;
    background-color: #ffffff;
}
.diagnosis .group {
    padding: 60px 0;
}
.diagnosis .group .img {
    padding: 30px 0;
}
.diagnosis .staging .img {
    padding: 30px 0;
    position: relative;
    z-index: 99;
}
.diagnosis .staging p {
    margin-top: 30px;
}
.medicine {
    padding: 90px 0;
}
.medicine .medicine-row {
    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 20px;
    padding: 90px 0 50px;
}
.medicine .medicine-box {
    background-color: #ffffff;
    padding: 50px 20px 20px 40px;
    border-radius: 14.22px; 
    position: relative;
    box-shadow: 0 3.95px 50px rgba(206, 206, 206, 0.25);
    border: 1px solid #E7E9F0;
}
.medicine .medicine-box span {
    font-size: 30px;
    font-weight: bold;
    width: 54px;
    height: 54px;
    background-color: #D8E6FC;
    color: #0A69FA;
    border-radius: 50%; 
    position: absolute;
    display: flex;
    align-items: center;
    justify-content: center;
    top: -30px;
    left: 50%;
    transform: translateX(-50%);
}
.medicine .medicine-box p{
    max-width: 253px;
    min-height: 262px;
}
.benefits-recommendations {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 20px;
    padding: 50px 0;
}
.benefits-container {
    width: 645px;
    height: 873px;
    background-color: #7257FF; /* Cor de fundo para a máscara */
    border-radius: 24px; /* Raio de borda da máscara */
    position: relative;
    padding: 90px;
    display: flex;
    flex-direction: column;
    justify-content: center;
}
.benefits-container img {
    position: absolute;
    top: 5px;
    left: 0;
}
.benefits-container h3 {
    color: #ffffff;
    margin-bottom: 30px;
}
.benefits-container p {
    color: #ffffff;
    margin-bottom: 30px;
}
.benefits-container ul li {
    background-color: #ffffff;
    padding: 20px 70px 20px;
    border-radius: 12px; 
    font-size: 16px;
    position: relative;
}
.benefits-container ul li::before {
    content: '';
    position: absolute;
    left: 40px; 
    top: 26%; 
    transform: translateY(-50%); 
    width: 13px;
    height: 13px;
    background-color: #0A69FA; 
    border-radius: 50%; 
  }
.benefits-container:last-child ul li::before {
    top: 50%;
}
.guidelines h3 {
    margin-bottom: 40px;
}
.guidelines p:nth-child(2) {
    margin-top: 30px;
}
.guidelines-row {
    display: flex;
    align-items: flex-start;
    justify-content: center;
    gap: 20px;
    padding: 50px 0;
}
.guidelines-row ul li {
    min-width: 420px;
    padding: 30px 20px 30px 60px;
    background-color: #0B6AFB;
    color: #ffffff;
    border-radius: 12px;
    filter: drop-shadow(0px 3.944px 49.299px rgba(0, 0, 0, 0.25));
    margin-bottom: 20px;
}
.guidelines-row .guidelines-colum:nth-child(2) ul li {
    padding-right: 40px;
    padding-bottom: 5px;
}
.guidelines-row .guidelines-colum:nth-child(2) ul li p{
    position: relative;
    padding-left: 10px;
}
.guidelines-row .guidelines-colum:nth-child(2) ul li p::before {
    content: '';
    position: absolute;
    left: -20px; 
    top: 26%; 
    transform: translateY(-50%); 
    width: 17px;
    height: 12px;
    background-image: url(../img/prostata/arrow-box.svg);
    background-size: 17px;
}
.guidelines-row .guidelines-colum:nth-child(2) ul li p:nth-last-child(3)::before {
    top: 12%;
}
.guidelines-row .guidelines-colum:nth-child(2) ul li p:nth-last-child(2)::before {
    top: 20%;
}
.guidelines-row .guidelines-colum:nth-child(2) ul li p:last-child::before {
    top: 50%;
}
.guidelines-row ul li::before {
    content: '';
    position: absolute;
    left: 30px; 
    top: 49%; 
    transform: translateY(-50%); 
    width: 13px;
    height: 13px;
    background-color: #ffffff; 
    border-radius: 50%; 
}
.guidelines-row .guidelines-colum:nth-child(2) ul li::before {
    top: 10%;
}
.guidelines-row .guidelines-colum:nth-child(3) ul li:last-child::before {
    top: 22%;
}
.testing {
    position: relative;
    padding: 100px 0;
}
.testing img {
    position: absolute;
    bottom: 120px;
    left: 0;
}
.testing-box {
    position: relative;
    background-color: #0A69FA;
    padding: 44px 100px 40px;
    border-radius: 12px;
    box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    display: flex;
    flex-direction: column;
    justify-content: center;
    margin: 0 230px;
}
.testing-box p {
    color: #ffffff;
}
.esmo {
    padding: 90px 0;
}u
.esmo h3 {
    margin-bottom: 30px;
}
.esmo-grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 20px;
}
.esmo-grid-item-one {
    background: url(../img/prostata/bg-1.png) center center / cover no-repeat;
    padding: 30px 50px 80px;
    margin: 20px;
    border-radius: 12px;
   
}
.esmo-grid-item-one p>strong {
    color: #2473FD;
}
.esmo-grid-item-one p {
    color: #2E4070;
}
.esmo-grid-item-two {
    background: url(../img/prostata/bg-2.png) center center / cover no-repeat;
    padding: 30px 50px 80px;
    margin: 20px;
    border-radius: 12px;
}
.esmo-grid-item-two p {
    color: #ffffff;
}
.esmo .box-warnings {
    padding: 150px 0 0;
}
.esmo .box-warnings .box-warnings-title {
    background-color: #1333A1;
    color: #ffffff;
    padding: 30px 0 20px 40px;
    border-radius: 6px 6px 0 0;
}
.esmo .box-warnings .box-warnings-title h6 {
    font-size: 1.125rem;
    font-family: "Inter", sans-serif;
}
.esmo .box-warnings .box-warnings-content {
    background-color: #E7ECF5;
    color: #374151;
    border-radius: 0 0 6px 6px; 
    padding-left: 40px;
}
.esmo .box-warnings .box-warnings-content ul {
    padding-right: 50px;
    margin: 0;
}
.esmo .box-warnings .box-warnings-content ul li {
    list-style: none;
    padding: 30px 0 30px 40px;
    margin-bottom: 0;
    position: relative;
}
.esmo .box-warnings .box-warnings-content ul li:first-child {
    border-bottom: 1px dashed #CACACA;
}
.esmo .box-warnings .box-warnings-content ul li:nth-child(2) {
    border-bottom: 1px dashed #CACACA;
}
.esmo .box-warnings .box-warnings-content ul li a {
    color: #1333A1;
    font-weight: bold;
}
.esmo .box-warnings .box-warnings-content ul li a:first-child {
    text-decoration: none;
}
.esmo .box-warnings .box-warnings-content ul li:before {
    content: '';
    position: absolute;
    width: 32px;
    height: 32px;
    background-size: 20px;
    background-repeat: no-repeat;
    left: 6px;
    top: 58%;
    transform: translateY(-50%);
    background-image: url(../img/prostata/exclama.svg);
}
.staging h3 {
    margin-bottom: 0;
}
.diagnosis::after {
    content: '';
    position: absolute;
    background-image: url(../img/prostata/bg-estadiamento.svg);
    background-repeat: no-repeat;
    width: 1486px;
    height: 1486px;
    right: 0;
    bottom: 1780px;
}
.guidelines {
    background-color: #ffffff;
}
/* Section ref-footer */
.ref-footer {
    padding: 0 0 90px;
}
.ref-footer p {
    font-size: 12px;
    line-height: 20px;
}
.ref-footer p:last-child {
    margin-bottom: 0;
}
/* end Section ref-footer */

/* Responsive */
@media (max-width: 1540px) {
    .epidemiology .epidemiology-box::before {
        right: -60px;
    }
    
}
@media (max-width: 1400px) {
    .signs .signs-row {
        display: grid;
        grid-template-columns: 1fr 1fr 1fr;
    }
    .guidelines-row {
        display: grid;
    }
    .epidemiology .epidemiology-box::before {
        right: 0;
    }
    .banner nav .navbar-nav .nav-link {
        padding: .5rem 10px;
    }
    .medicine .medicine-row {
        display: grid;
        grid-template-columns: 1fr 1fr;
    }
}
@media (max-width: 1200px) {
    .banner nav .navbar-nav .nav-link {
        font-size: 15px;
    }
    .epidemiology .epidemiology-box, .brazil .brazil-box {
        padding: 50px;
    }
    .benefits-container {
        height: auto;
        width: 100%;
    }
    .benefits-recommendations {
        display: grid;
    }
    .testing img {
        bottom: 220px;
    }
}
@media (max-width: 991px) {
    .signs .signs-row {
        display: grid;
        grid-template-columns: 1fr 1fr;
    }
    .banner nav {
        display: none;
    }
    .banner .title {
        padding: 90px 0;
    }
    .banner {
        height: auto;
    }
    .img img {
        max-width: none!important;
        width: unset;
    }
    .img {
        width: 100%;
        overflow: auto;
    }
    .epidemiology .grid {
        display: grid;
    }
    .diagnosis .grid .diagnosis-item img {
        display: none;
    }
    .diagnosis .grid {
        grid-template-columns: 2fr;
    }
    .testing-box {
        margin: 0;
    }
    .esmo-grid-item-two {
        background: #1E6FFF;
        padding: 50px;
    }
    section br {
        display: none;
    }
}
@media (max-width: 768px) {
    .esmo .box-warnings .box-warnings-content {
        background-color: #E7ECF5;
        color: #374151;
        border-radius: 0 0 6px 6px;
        padding-left: 15px;
    }
    h2 {
        font-size: 25px;
        line-height: 30px;
    }
    h3 {
        font-size: 25px;
        line-height: 30px;
    }
    .banner .title h2 {
        font-size: 35px;
        line-height: 40px;
    }
    .banner .title p {
        font-size: 20px;
        line-height: 26px;
    }
    .banner {
        padding: 70px 0;
        height: 320px;
        background-size: 1563px;
        display: flex;
        align-items: center;
    }
    .banner .title {
        padding: 0;
    }
    .epidemiology .epidemiology-box {
        margin-top: 30px;
    }
    .epidemiology .title {
        padding-top: 70px;
    }
    .brazil {
        padding: 50px 0;
    }
    .brazil .brazil-container {
        margin: 0;
    }
    .brazil .brazil-box {
        margin: 70px 0 0;
    }
    .signs .signs-row, .medicine .medicine-row {
        grid-template-columns: 1fr;
    }
    .signs {
        padding: 60px 0;
    }
    .medicine .medicine-row {
        text-align: center;
        padding-top: 30px;
    }
    .medicine .medicine-box p {
        max-width: 100%;
        min-height: auto;
    }
    .benefits-container {
        padding: 50px;
    }
    .medicine {
        padding: 90px 0 0;
    } 
    .testing {
        padding: 50px 0 0;
    }
    .testing-box {
        padding: 50px;
    }
    .esmo-grid {
        grid-template-columns: 1fr;
    }
    .esmo .box-warnings {
        padding: 50px 0 0;
    }
    .esmo .box-warnings .box-warnings-content ul li a {
        font-size: 14px;
    }
    .guidelines-row ul li {
        min-width: 100%;
    }
    .epidemiology .grid {
        display: block;
    }
    .diagnosis .grid .diagnosis-item ul li {
        padding: 40px 30px 30px;
    }
    .diagnosis .grid .diagnosis-item ul li h3 {
        font-size: 20px;
        line-height: 25px;
    }
}