html {
    height: 100%;
}

body {
    color: #4B4B4B;
    line-height: 24px;
    font-size: 1rem;
    height: 100%;
    font-family: 'Inter', sans-serif;
    background: #ffffff;
}

img {
    width: 100%;
}

a {
    color: #4B4B4B;
}

sub,
sup {
    font-size: .55em;
}
p {
    font-size: 16px;
    line-height: 24px;
}

span {
    font-weight: 700;
}

ul li {
    position: relative;
    list-style: none;
}
h1 {
    font-size: 48px;
}
.desktop-none {
    display: none;
}
.container-fluid {
    padding: 0 120px;
    max-width: 1686px;
    margin: 0 auto;
}
.img-border {
    border-top-left-radius: 20px;
    border-bottom-left-radius: 20px;
}
/* ENDE GENRAL */
.banner {
    background-image: url('../img/banner.webp');
    position: relative;
    width: 100%;
    background-repeat: no-repeat;
    background-position: top left;
    background-size: contain;
}
.banner .title {
    padding: 60px 0 40px;
}
.banner .title h1 {
    font-size: 55px;
    line-height: 62px;
    margin-bottom: 20px;
}
.banner .title h1, .banner .title p {
    color: #ffffff;
}
.banner .shortcuts p {
    font-size: 12px;
    margin-bottom: 20px;
    color: #ffffff;
}
.banner .shortcuts ul {
    padding: 0;
    margin: 0;
}
.banner .shortcuts ul li {
    position: relative;
    max-width: 530px;
    font-size: 18px;
    line-height: 1.5;
    background-color: #FFFCFD;
    padding: 25px;
    margin-bottom: 2px;
    border-left: #F7F6FF solid 4px;
}
.banner .shortcuts ul li.active:hover {
    background-color: #E0DCFF;
    border-left: #291F8C solid 4px;
    color: #291F8C;
    font-weight: 700;
    transition: all .2s;
}
.banner .shortcuts ul li.active a {
    color: #291F8C;
}
.banner .shortcuts ul li a {
    color: #505050;
    text-decoration: none;
}
.about .content {
    padding: 90px 0;
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 80px;
}
.about .content .btm h2 {
    font-size: 35px;
    font-weight: 700;
    line-height: 42px;
    color: #002028;
    margin-bottom: 30px;
}
.about .content .btm .bt {
    padding: 14px 20px;
    border-radius: 6px;
    align-items: center;
    background: #291F8C;
    color: #ffffff;
    display: inline-flex;
    text-decoration: none;
    margin-bottom: 30px;
}
.about .content .btm .grid-bt {
    display: flex;
    align-items: center;
    gap: 30px;
}
.about .content .btm .grid-bt p {
    padding: 14px 0;
    color: #291F8C;
    line-height: 24px;
    font-weight: 700;
    margin-bottom: 30px;
}
.about .content .btm .bt img {
    width: 13px;
    margin-left: 10px;
}
.about .content .btm a {
    text-decoration: none;
    color: #291F8C;
    font-weight: 700;
}
.medicines {
    padding: 90px 0 60px;
}
.medicines .title h2 {
    position: relative;
    font-size: 55px;
    line-height: 62px;
    color: #002028;
    font-weight: 700;
    margin-bottom: 10px;
}
.medicines .title p {
    max-width: 600px;
}
.medicines .boxs {
    margin-top: 50px;
    display: grid;
    grid-template-columns: repeat(5, 1fr);
    gap: 20px;
}
.medicines .boxs .item {
    display: flex;
    align-items: center;
    justify-content: center;
    height: 140px;
    padding: 20px;
    background-color: #ffffff;
    border-radius: 20px;
    box-shadow: 0 0 20px rgba(190, 190, 190, 0.25);
}
.medicines .boxs .item img {
    width: auto;
    max-width: 100%;
    height: auto;
    max-height: 90px;
    object-fit: contain;
}
.info-carousel .owl-carousel .item img {
    width: 100%;
    height: auto;
    border-radius: 10px;
}
.info-carousel {
    padding: 110px 0;
    background-color: #FFF8E7;
}
.info-carousel .title h2, .therapeutic-areas .title h2, .pillars .title h2 {
    position: relative;
    font-size: 55px;
    line-height: 62px;
    color: #002028;
    font-weight: 700;
    margin-bottom: 30px;
}
.info-carousel .title h2::after, .therapeutic-areas .title h2::after, .pillars .title h2::after {
    content: '';
    position: absolute;
    top: -165px;
    width: 250px;
    height: 247px;
    background-image: url(../img/carta.webp);
    margin-left: -20px;
}
.info-carousel .owl-carousel .owl-nav button.owl-next, .info-carousel .owl-carousel .owl-nav button.owl-prev, .info-carousel .owl-carousel button.owl-dot {
    color: #C4C4C4;
    border: none;
    font: inherit;
    background: #291F8C;
    border-radius: 50%;
    width: 50px;
    height: 50px;
    font-size: 40px;
    font-weight: 100;
}
.info-carousel .owl-theme span {
    font-weight: 300;
    position: relative;
    top: -2px;
}
.info-carousel .owl-theme .owl-nav {
    margin-top: 10px;
    position: absolute;
    top: -80px;
    right: 20px;
}
.therapeutic-areas {
    padding: 120px 0 50px;
}
.therapeutic-areas .title h2::after {
    top: -60px;
    width: 212px;
    height: 215px;
    background-size: 195px;
    background-image: url(../img/pessoa.webp);
    background-repeat: no-repeat;
    margin-left: 0;
}
.therapeutic-areas .boxs {
    margin-top: 50px;
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 20px;
}
.therapeutic-areas .boxs .item {
    display: flex;
    align-items: center;
    gap: 30px;
    box-shadow: 0 0 20px rgba(190, 190, 190, 0.25);
    border-radius: 20px;
}
.therapeutic-areas .boxs .item .text {
    padding: 0 30px 0 0;
}
.therapeutic-areas .boxs .item h5 {
    font-size: 24px;
    line-height: 24px;
    font-weight: 700;
}
.therapeutic-areas .boxs .item a {
    display: inline-block;
    color: #291F8C;
    padding: 13px 20px;
    border-radius: 7px;
    border: solid 1px;
    text-decoration: none;
}
.therapeutic-areas .boxs .item img {
    width: 195px;
    min-height: 200px;
    border-radius: 20px 0 0 20px;
}
.therapeutic-areas .boxs .item a.active {
    color: #ffffff;
    background-color: #291F8C;
}
.emphasis .box {
    position: relative;
    padding: 120px;
    display: flex;
    align-items: center;
    border-radius: 30px;
    background: linear-gradient(135deg, #EEA800 0%, #FFB500 100%);
}
.emphasis .box .title a {
    padding: 14px 25px;
    border-radius: 6px;
    align-items: center;
    background: #291F8C;
    color: #ffffff;
    display: inline-flex;
    text-decoration: none;
    margin-top: 30px;
}
.emphasis .box .img img {
    position: absolute;
    top: -60px;
    right: 0;
    width: 900px;
}

/* content-filter */
.content-filter {
    background-color: #FFF6DF;
    background-color: #FFF6DF;
    padding: 80px 0;
    border-radius: 20px;
    margin: 0 20px;
}
.content-filter .title h2 {
    position: relative;
    font-size: 55px;
    line-height: 62px;
    color: #002028;
    font-weight: 700;
    margin-bottom: 30px;
}
.content-filter .title h2::after {
    content: '';
    position: absolute;
    top: -110px;
    width: 250px;
    height: 210px;
    background-size: 230px;
    background-image: url(../img/bonecoartigo.webp);
    background-repeat: no-repeat;
    margin-left: 0;
}
.content-filter .content-box {
    padding: 40px 30px 30px;
    display: flex;
    align-items: center;
    gap: 30px;
    background-color: #ffffff;
    margin-top: 50px;
    margin-bottom: 50px;
}
.content-filter .content-box p.medium {
    font-size: 14px;
    color: #374151;
    margin-bottom: 0;
}
.content-filter .content-box p.small {
    font-size: 12px;
    color: #999999;
}
.content-filter .content-box label {
    display: flex;
    font-weight: 700;
    align-items: center;
    gap: 5px;
}
.content-filter h3 {
    color: #111827;
    font-size: 24px;
    font-weight: 700;
}
input[type="checkbox"]:checked {
    border-color: #291F8C;
    background-color: #291F8C;
}
input[type="checkbox"] {
    width: 20px;
    height: 20px;
    border: 2px solid #D3D3D3;
    border-radius: 4px;
    appearance: none;
    -webkit-appearance: none;
    -moz-appearance: none;
    outline: none;
    cursor: pointer;
}
input[type="checkbox"]:checked::after {
    content: "\2714";
    color: white;
    font-size: 16px;
    display: flex;
    justify-content: center;
    align-items: center;
    position: relative;
    top: -4px;
}
.content-filter #conteudo-lista .card-flex {
    margin: 20px 0px 20px 0;
    display: flex;
    gap: 30px;
    background-color: #ffffff;
    border-radius: 20px;
}
.content-filter #conteudo-lista .card-flex .thumb img {
    width: 195px;
    height: fit-content;
}
.content-filter #conteudo-lista .card-flex .card-body {
    align-content: center;
}
.content-filter #conteudo-lista .card-flex .card-body a {
    text-decoration: none;
}
.content-filter #conteudo-lista .card-flex .card-body h5 {
    font-size: 20px;
    font-weight: bold;
    color: #002028;
    max-width: 580px;
    margin-bottom: 20px;
}
.content-filter #conteudo-lista .card-flex .bt {
    align-content: center;
    padding-right: 50px;
}
.content-filter #conteudo-lista .card-flex .bt .btn-primary {
    width: 110px;
    padding: 10px;
    color: #291F8C;
    background-color: #ffffff;
    border-color: #291F8C;
    border-radius: 8px;
}
.content-filter #conteudo-lista .card-flex .bt .btn-primary.active {
    color: #ffffff;
    background-color: #291F8C;
    border-color: #291F8C;
}
/* content-filter */
.pillars {
    background-color: #FFF6DF;
    padding: 90px 0;
    border-radius: 20px;
    margin: 0 20px;
}
.pillars .boxs {
    display: grid;
    grid-template-columns: 1fr 1fr 1fr;
    gap: 20px;
}
.pillars .boxs .item {
    position: relative;
    padding: 30px;
    text-align: center;
    background-color: #ffffff;
    border-radius: 40px;
    box-shadow: 0 0 20px rgba(190, 190, 190, 0.25);
}
.pillars .boxs .item .icon img {
    width: 180px;
    min-height: 150px;
}
.pillars .boxs .item .text h3 {
    font-size: 24px;
    margin: 30px 0;
    color: #002028;
    font-weight: 700;
}
.pillars .boxs .item a {
    font-weight: 700;
    text-decoration: none;
}
.pillars .boxs .item a.bt {
    color: #291F8C;
}
.pillars .boxs .item a.bt img {
    width: 15px;
}
.pillars .boxs .item p.min {
    font-size: 12px;
}
.pillars .title h2::after {
    top: -130px;
    width: 220px;
    height: 275px;
    background-image: url(../img/pilares.webp);
    margin-left: -10px;
    background-size: 225px;
    background-repeat: no-repeat;
}
.events.therapeutic-areas .boxs .item {
    margin-bottom: 20px;
}
.events.therapeutic-areas .boxs h3 {
    font-size: 24px;
    margin-bottom: 30px;
    font-weight: 700;
    color: #111827;
}
.events.therapeutic-areas .title h2::after {
    top: -90px;
    width: 250px;
    height: 210px;
    background-size: 250px;
    background-image: url(../img/bonecoevento.webp);
    background-repeat: no-repeat;
    margin-left: 0;
}
.ref {
    padding: 60px 0;
    text-align: center;
}
.ref .container {
    position: relative;
}
.ref .container .scr-footer img {
    top: -110;
    right: 0;
    position: absolute;
    width: 170px;
    cursor: pointer;
}
@media (min-width: 1921px) {
    .banner {
        background-size: cover;
    }
}
@media (max-width: 1660px) {
    .banner {
        background-position-x: -140px;
        background-size: 1820px;
    }
}
@media (max-width: 1500px) {
    .banner {
        background-position-x: -150px;
        background-size: 1640px;
    }
}
@media (max-width: 1350px) {
    .banner {
        background-position-x: -220px;
        background-size: 1580px;
    }
}
@media (max-width: 1199px) {
    .banner {
        background-position-x: -345px;
        background-size: 1530px;
    }
    .therapeutic-areas .boxs .item h5 {
        font-size: 18px;
        line-height: 20px;
    }
    .therapeutic-areas .boxs .item .text {
        padding: 0 20px 0 0;
    }
    .ref .container .scr-footer img {
        top: -160px;
        width: 150px;
    }
}

@media (max-width: 991px) {
    .banner {
        background-position-x: 0;
        background-size: 1950px;
    }
    .grid {
        grid-template-columns: 1fr;
        gap: 50px;
    }
    .about .content {
        grid-template-columns: 1fr;
        gap: 40px;
    }
    .info-carousel p, .pillars .title h2, .therapeutic-areas .title h2 {
        max-width: 82%;
    }
    .therapeutic-areas .boxs, .pillars .boxs {
        grid-template-columns: 1fr;
    }
    .pillars .title h2::after {
        top: -70px;
        right: -143px;
        width: 200px;
        background-size: 210px;
    }
    .medicines .boxs {
        grid-template-columns: repeat(3, 1fr);
    }
    .medicines .title h2 {
        max-width: 82%;
    }

}

@media (max-width: 768px) {
    .banner .title {
        padding: 60px 0 20px;
    }
    .banner .title h1 {
        font-size: 50px;
        line-height: 58px;
    }
    .banner .shortcuts ul li {
        max-width: 90%;
    }
    .info-carousel .title h2::after {
        width: 200px;
        background-size: 200px;
        background-repeat: no-repeat;
        top: -157px;
        margin-left: 0;
        right: 0;
    }
    .info-carousel .title h2, .therapeutic-areas .title h2, .pillars .title h2, .medicines .title h2 {
        font-size: 45px;
        line-height: 55px;
    }
    .medicines .boxs {
        grid-template-columns: repeat(2, 1fr);
    }
    .medicines .boxs .item {
        height: 110px;
    }
    .medicines .boxs .item img {
        max-height: 70px;
    }
    .therapeutic-areas .title h2::after {
        background-size: 120px;
        right: -30px;

    }
    .info-carousel .owl-theme .owl-nav {
        top: 170px;
        right: 0;
    }
    .therapeutic-areas .boxs .item {
        gap: 10px;
    }
    .therapeutic-areas .boxs .item img {
        width: 175px;
    }
    .therapeutic-areas .boxs .item a {
        padding: 10px 20px;
    }
    .pillars .title h2::after {
        top: -118px;
        right: -49px;
        width: 195px;
        background-size: 154px;
    }
    .events.therapeutic-areas .title h2::after {
        right: -79px;
        background-size: 184px;
        width: 180px;
    }
    .events.therapeutic-areas .list .item  .text p {
        display: none;
    }
    .content-filter .title h2::after {
        width: 150px;
        background-size: 150px;
    }
    .content-filter .content-box {
        flex-direction: column;
        align-items: self-start;
    }
    .content-filter #conteudo-lista .card-flex {
        display: grid;
        grid-template-columns: 1fr 1fr;
        gap: 0;
        position: relative;

    }
    .content-filter #conteudo-lista .card-flex .card-body {
        padding-top: 10px;
        align-content: flex-start;
    }
    .content-filter #conteudo-lista .card-flex .card-body p {
        display: none;
    }
    .content-filter #conteudo-lista .card-flex .thumb img {
        width: 160px;
    }
    .content-filter #conteudo-lista .card-flex .bt {
        position: absolute;
        bottom: 10px;
        right: 10px;
    }
    .content-filter #conteudo-lista .card-flex .card-body h5 {
        font-size: 18px;
    }

}
@media (max-width: 414px) {
    .banner .title h1 {
        font-size: 42px;
        line-height: 52px;
    }
    .info-carousel .title h2, .therapeutic-areas .title h2, .pillars .title h2, .medicines .title h2 {
        font-size: 35px;
        line-height: 45px;
    }
    .medicines .boxs {
        grid-template-columns: repeat(2, 1fr);
        gap: 10px;
    }
    .about .content {
        padding: 70px 0;
    }
    .about .content .btm .grid-bt {
        gap: 20px;
    }
    .therapeutic-areas .title h2::after {
        width: 150px;
    }
    .therapeutic-areas .boxs .item img {
        width: 160px;
    }
    .therapeutic-areas .boxs .item .text p {
        display: none;
    }
    .pillars .title h2::after {
        top: -130px;
        width: 150px;
    }
    .pillars .title h2::after {
        top: -110px;
        right: -85px;
        width: 110px;
        background-size: 110px;
    }
    .events.therapeutic-areas .title h2::after {
        top: -120px;
        right: -70px;
        background-size: 162px;
        width: 162px;
    }
    .content-filter .title h2::after {
        width: 100px;
        background-size: 100px;
    }
    .content-filter #conteudo-lista .card-flex .thumb img {
        width: 140px;
    }
    .content-filter #conteudo-lista .card-flex .card-body h5 {
        font-size: 16px;
    }
    .content-filter #conteudo-lista .card-flex .bt {
        bottom: 8px;
        right: -11px;
    }
    .content-filter #conteudo-lista .card-flex .bt .btn-primary {
        padding: 8px;
    }

}